SML2678
A-770041
≥98% (HPLC)
别名:
A 770041, A770041, N-[4-[1-[trans-4-(4-Acetyl-1-piperazinyl)cyclohexyl]-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]-1-methyl-1H-indole-2-carboxamide, trans-KIN 001-111
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关于此项目
经验公式（希尔记法）:
C34H39N9O3
化学文摘社编号:
分子量:
621.73
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
A-770041, ≥98% (HPLC)
InChI
1S/C34H39N9O3/c1-21(44)41-14-16-42(17-15-41)24-9-11-25(12-10-24)43-33-30(32(35)36-20-37-33)31(39-43)23-8-13-26(29(19-23)46-3)38-34(45)28-18-22-6-4-5-7-27(22)40(28)2/h4-8,13,18-20,24-25H,9-12,14-17H2,1-3H3,(H,38,45)(H2,35,36,37)
SMILES string
NC1=NC=NC2=C1C(C3=CC=C(NC(C4=CC(C=CC=C5)=C5N4C)=O)C(OC)=C3)=NN2[C@@H]6CC[C@@H](N7CCN(C(C)=O)CC7)CC6
InChI key
ZMNWFTYYYCSSTF-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Biochem/physiol Actions
A-770041 is an orally available (rat F = 34.1%; 10 mg/kg p.o.), ATP-competitive, potent and selctive Lck inhibtor (IC50 = 147 nM/Lck, 1.18 μM/Lyn, 1.22 μM/Hck, 9.05 μM/Src, 14.1 μM/Fgr, 44.1 μM/Fyn; >25 μM/IKK1, IKK2, IRAK4, p38, JAK3, ZAP70, ITK, PKC, MK2, PKA, TYK2, COT,Syk; >50 μM/Tie-2 & Kdr; 1 mM ATP). A-770041 inhibits CD3 mAb-induced IL-2 production in human whole blood in vitro (IC 50 = 80 nM) and in mice in vivo (IC50 = 78 nM plasma conc.), and significantly lengthens graft survival time in a rat heterotopic heart transplant model (2.5 & 5 mg/kg bid p.o.).
Orally available, ATP-competitive, potent and selctive Lck inhibtor with immune suppression efficacy in vitro and in vivo.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Andrew Burchat et al.
Bioorganic & medicinal chemistry letters, 16(1), 118-122 (2005-10-12)
We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
Yu-Jing Wu et al.
Frontiers in pharmacology, 9, 4-4 (2018-02-08)
Researchers have shown that the level of immunoglobulin D (IgD) is often elevated in patients with autoimmune diseases. The possible roles of IgD on the function of human T cell activation are still unclear. Paeoniflorin-6'-O-benzene sulfonate (code: CP-25), the chemistry
J P Zepecki et al.
Oncogene, 38(10), 1734-1750 (2018-10-26)
Migration of human glioma cells (hGCs) within the brain parenchyma makes glioblastoma one of the most aggressive and lethal tumors. Studies of the cellular and molecular mechanisms underlying hGC migration are hindered by the limitations of existing glioma models. Here
X Li et al.
Allergy, 73(2), 361-368 (2017-09-01)
In mast cells, induction of HSP70 expression during antigen stimulation has not been reported. Mouse bone marrow-derived mast cells (BMMC) were stimulated with IgE/Ag or HSP70. Induction of HSP70 expression and signaling protein phosphorylation were evaluated by immunoblotting. HSP70 expression
Zhenfeng Duan et al.
BMC cancer, 14, 681-681 (2014-09-23)
Reversing multidrug resistance (MDR) has been an important goal for clinical and investigational oncologists. In the last few decades, significant effort has been made to search for inhibitors to reverse MDR by targeting ATP-binding cassette (ABC) transporters (Pgp, MRP) directly
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