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Merck
CN

SML2696

RSM932A

≥97% (HPLC)

别名:

1,1′-[[1,1′-Biphenyl]-4,4′-diylbis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium dibromide (9CI), 1,1′-[[[1,1′-Biphenyl]-4,4′-diyl]bis(methylene)]bis[4-[(4-chlorophenyl)methylamino]-quinolinium] bromide, RSM 932A, TCD-717

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关于此项目

经验公式（希尔记法）:
C46H38Cl2N4 · 2Br
化学文摘社编号:
850807-63-5
分子量:
877.53
UNSPSC Code:
12352200
NACRES:
NA.77

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InChI

1S/C46H38Cl2N4/c1-49(39-23-19-37(47)20-24-39)43-27-29-51(45-9-5-3-7-41(43)45)31-33-11-15-35(16-12-33)36-17-13-34(14-18-36)32-52-30-28-44(42-8-4-6-10-46(42)52)50(2)40-25-21-38(48)22-26-40/h3-30H,31-32H2,1-2H3/q+2

InChI key

QGYGTMZEJNOHNU-UHFFFAOYSA-N

SMILES string

CN(C1=CC=[N+](CC2=CC=C(C3=CC=C(C[N+]4=CC=C(N(C5=CC=C(Cl)C=C5)C)C6=CC=CC=C46)C=C3)C=C2)C7=CC=CC=C17)C8=CC=C(Cl)C=C8

assay

≥97% (HPLC)

form

powder

storage condition

desiccated

color

faint yellow to dark orange

solubility

H2O: 2 mg/mL, clear

storage temp.

2-8°C

相关类别

Biochem/physiol Actions

RSM932A is a potent and selective choline kinase a (ChoKa, CHKA) inhibitor that induces apoptosis in cancer cells via prolonged activation of ER stress response and C/EBP homologous protein (CHOP) overproduction. RSM932A decreases de novo in phosphatidylcholine synthesis and increases ceramides levels that selectively trigger apoptosis in cancer cells. On the other hand, RSM932A induces reversible G0/G1 cell cycle arrest in nontumorigenic cells. RSM932A exhibits potent antiproliferative activity in array of human cancer cell lines.
potent and selective choline kinase a (ChoKa, CHKA) inhibitor that induces apoptosis in cancer cells

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000154814
0000090443
0000090444
0000082926

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Sean P Arlauckas et al.
Oncotarget, 8(10), 16518-16530 (2017-02-06)
Choline kinase alpha (ChoKα) overexpression is associated with an aggressive tumor phenotype. ChoKα inhibitors induce apoptosis in tumors, however validation of their specificity is difficult in vivo. We report the use of optical imaging to assess ChoKα status in cells
E Sanchez-Lopez et al.
Cell death & disease, 4, e933-e933 (2013-11-30)
Endoplasmic reticulum (ER) is a central organelle in eukaryotic cells that regulates protein synthesis and maturation. Perturbation of ER functions leads to ER stress, which has been previously associated with a broad variety of diseases. ER stress is generally regarded
Juan Carlos Lacal et al.
Molecular cancer therapeutics, 14(1), 31-39 (2014-12-10)
Choline kinase α (CHKA; here designated as ChoKα) is the first enzyme in the CDP-choline pathway, implicated in phospholipids metabolism. It is overexpressed in several human tumors such as breast, lung, bladder, colorectal, prostate, ovary, and liver. The overexpression of

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