SML2762
RG1534
≥98% (HPLC)
别名:
2-Amino-N-((4-((5-chloropyrimidin-2-yl)oxy)-3-methylphenyl)carbamoyl)benzamide, 2-Amino-N-[[[4-[(5-chloro-2-pyrimidinyl)oxy]-3-methylphenyl]amino]carbonyl]benzamide;
InChI
1S/C19H16ClN5O3/c1-11-8-13(6-7-16(11)28-19-22-9-12(20)10-23-19)24-18(27)25-17(26)14-4-2-3-5-15(14)21/h2-10H,21H2,1H3,(H2,24,25,26,27)
InChI key
NLVSCQFSPVSAOF-UHFFFAOYSA-N
SMILES string
NC1=CC=CC=C1C(NC(NC2=CC(C)=C(C=C2)OC3=NC=C(C=N3)Cl)=O)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
inhibitor of hTERT promoter activity that selectively targets G-hairpin stem loop of the human telomerase reverse transcriptase gene (hTERT)
RG1534 is an inhibitor of hTERT promoter activity that selectively targets G-hairpin stem loop of the human telomerase reverse transcriptase gene (hTERT) that downregulates hTERT expression. RG1534 induces mitochondrial defects, oxidative stress, DNA damage and apoptosis in cancer cell while sparing normal cells
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Jin H Song et al.
Cell chemical biology, 26(8), 1110-1121 (2019-06-04)
Increased telomerase activity is associated with malignancy and poor prognosis in human cancer, but the development of targeted agents has not yet provided clinical benefit. Here we report that, instead of targeting the telomerase enzyme directly, small molecules that bind
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