SML2771
Amonafide
≥98% (HPLC)
别名:
5-Amino-2-[2-(dimethylamino)ethyl]-1H-benz[de]isoquinoline-1,3(2H)-dione, AS1413, FA 142, NSC 308847, Nafidimide
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关于此项目
经验公式（希尔记法）:
C16H17N3O2
化学文摘社编号:
分子量:
283.33
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
Amonafide, ≥98% (HPLC)
SMILES string
[n]1([c](c2c3c([c]1=O)cccc3cc(c2)N)=O)CCN(C)C
InChI
1S/C16H17N3O2/c1-18(2)6-7-19-15(20)12-5-3-4-10-8-11(17)9-13(14(10)12)16(19)21/h3-5,8-9H,6-7,17H2,1-2H3
InChI key
UPALIKSFLSVKIS-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Amonafide, a naphthalimides DNA intercalator, is a potent topoisomerase II inhibitor that inhibits tumor proliferation and progression. It appears that Amonafide inhibits melanoma progression through inhibition of the AKT/mTOR signaling pathway.
DNA intercalator and potent topoisomerase II inhibitor
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Design and synthesis of DNA-intercalative naphthalimide-benzothiazole/cinnamide derivatives: cytotoxicity evaluation and topoisomerase-IIa inhibition
Sankara Rao N, Nagesh N, Lakshma Nayak V, Sunkari S, Tokala R, Kiranmai G, Regur P, et al
MedChemComm, 10, 72-79 (2018)
Yingyi Ye et al.
Cancer management and research, 11, 2339-2348 (2019-04-10)
Human melanoma is a malignant tumor originated from melanocytes with high invasion, metastasis, and poor prognosis. In this study, the effects of naphthalimides UNBS5162 and amonafide on the properties of proliferation and apoptosis in human melanoma cells were confirmed. Cell
Ciara L Freeman et al.
Expert review of hematology, 5(1), 17-26 (2012-01-26)
Development of the novel topoisomerase II inhibitor, amonafide, began almost 40 years ago. The drug was selected for further investigation owing to evidence of marked antineoplastic efficacy in preclinical models of cancer. When its usefulness in the treatment of various
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