SML2795
IMP-1700
≥98% (HPLC)
别名:
1-Cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-7-[4-[thioxo[[4-(trifluoromethyl)phenyl]amino]methyl]-1-piperazinyl]-3-quinolinecarboxylic acid, 1-Cyclopropyl-6-fluoro-4-oxo-7-(4-((4-(trifluoromethyl)phenyl)carbamothioyl)piperazin-1-yl)-1,4-dihydroquinoline-3-carboxylic acid
InChI key
DMUZWIXJZNKJPP-UHFFFAOYSA-N
SMILES string
OC(C1=CN(C2CC2)C(C=C(N3CCN(C(NC4=CC=C(C=C4)C(F)(F)F)=S)CC3)C(F)=C5)=C5C1=O)=O
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
IMP-1700 is a cell-active and potent inhibitor of bacterial DNA repair that inhibits the bacterial SOS-response to DNA damage. IMP-1700 targets AddAB/RecBCD repair complex and potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus.
Inhibitor of bacterial DNA repair
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Carine S Q Lim et al.
Bioorganic & medicinal chemistry, 27(20), 114962-114962 (2019-07-17)
The global emergence of antibiotic resistance is one of the most serious challenges facing modern medicine. There is an urgent need for validation of new drug targets and the development of small molecules with novel mechanisms of action. We therefore
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