SML2801
6-乙酰-7-脱乙酰福斯考灵
≥95% (HPLC)
别名:
6β-乙酰氧基-1α,7β,9α-三羟基-8,13-环氧-异佛司可林-14-烯-11-酮, 异佛司可林
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关于此项目
经验公式（希尔记法）:
C22H34O7
化学文摘社编号:
分子量:
410.50
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
Quality Segment
assay
≥95% (HPLC)
form
powder
optical activity
[α]/D -8 to -5°, c = 0.5 in chloroform-d
color
white to beige
solubility
DMF:H2O (9:1): 2 mg/mL, clear
storage temp.
−20°C
SMILES string
CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C
InChI
1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1
InChI key
CLOQVZCSBYBUPB-VDCUXWMXSA-N
Biochem/physiol Actions
Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal
存储类别
11 - Combustible Solids
wgk
WGK 3
法规信息
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML2801-25MG | 04061841790891 |