SML2801

6-乙酰-7-脱乙酰福斯考灵

Name: 6-乙酰-7-脱乙酰福斯考灵
Brand: SIGMA

≥95% (HPLC)

别名:

6β-乙酰氧基-1α,7β,9α-三羟基-8,13-环氧-异佛司可林-14-烯-11-酮, 异佛司可林

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关于此项目

经验公式（希尔记法）:

C₂₂H₃₄O₇

化学文摘社编号:

64657-21-2

分子量:

410.50

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00078929

主要文件

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InChI

1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(28-12(2)23)17(26)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16?,17-,19-,20-,21+,22-/m0/s1

SMILES string

CC(=O)O[C@@H]1[C@H](O)[C@@]2(C)O[C@](C)(CC(=O)[C@]2(O)[C@@]3(C)[C@@H](O)CCC(C)(C)C13)C=C

InChI key

CLOQVZCSBYBUPB-VDCUXWMXSA-N

assay

≥95% (HPLC)

form

powder

optical activity

[α]/D -8 to -5°, c = 0.5 in chloroform-d

color

white to beige

solubility

DMF:H₂O (9:1): 2 mg/mL, clear

storage temp.

−20°C

Quality Level

100

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Biochem/physiol Actions

Isoforskolin is a naturally occurring diterpene with anti-inflammatory activity. It has been shown to downregulate the expression of proinflammatory compounds. In an experimental mouse model of Lyme Disease induced arthritis isoforskolin downregulated the transcription and expression of TNF-α and IL-6 induced by recombinant Borrelia burgdorferi basic membrane protein A (rBmpA). In a rat asthmatic model isoforskolin down-regulated production of transforming growth factor β1 (TGF-β1) and interleukin-1β (IL-1β) which was accompanied by inhibition of inflammation and airway remodeling.