SML2803
Tebanicline hydrochloride
≥98% (HPLC)
别名:
(R)-5-(2-Azetidinylmethoxy)-2-chloropyridine hydrochloride, (R)-5-(Azetidin-2-ylmethoxy)-2-chloropyridine hydrochloride, 5-((2R)-Azetidin-2-ylmethoxy)-2-chloropyridine hydrochloride, ABT-594 hydrochloride, Ebanicline hydrochloride
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关于此项目
经验公式（希尔记法）:
C9H11ClN2O · xHCl
化学文摘社编号:
分子量:
198.65 (free base basis)
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
Clc1ncc(cc1)OC[C@@H]2NCC2
InChI
1S/C9H11ClN2O/c10-9-2-1-8(5-12-9)13-6-7-3-4-11-7/h1-2,5,7,11H,3-4,6H2/t7-/m1/s1
InChI key
MKTAGSRKQIGEBH-SSDOTTSWSA-N
生化/生理作用
Partial agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes
Tebanicline (ABT-594) is a partial agonist at neural nicotinic acetylcholine receptors, binding to both the α3β4 and the α4β2 subtypes. It is a less toxic analog of epibatidine with potent antinociceptive effects.
警示用语：
Warning
危险声明
危险分类
STOT SE 3
靶器官
Central nervous system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Zhiyong Ding et al.
Psychopharmacology, 235(4), 1093-1105 (2018-01-15)
A novel rodent continuous performance test (CPT) was developed as one of the goals of the NEWMEDS (Novel Methods leading to New Medications in Depression and Schizophrenia) consortium to improve its translatability to the CPT test used in human subjects. The
Takafumi Hayashi et al.
Neuroscience letters, 638, 46-50 (2016-12-13)
Tebanicline (ABT-594), an analogue of epibatidine, exhibits potent antinociceptive effects and high affinity for the nicotinic acetylcholine receptor in the central nervous system. We assessed whether tebanicline exerts an effect on various noxious stimuli and mediates the nicotine receptor or
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