SML2813
UNC6934
≥98% (HPLC)
别名:
3-Oxo-3,4-dihydro-2H-benzo[1,4]oxazine-7-carboxylic acid cyclopropyl-[4-(pyrimidin-4-ylcarbamoyl)-benzyl]-amide
InChI
1S/C24H21N5O4/c30-22-13-33-20-11-17(5-8-19(20)27-22)24(32)29(18-6-7-18)12-15-1-3-16(4-2-15)23(31)28-21-9-10-25-14-26-21/h1-5,8-11,14,18H,6-7,12-13H2,(H,27,30)(H,25,26,28,31)
InChI key
KOZGEDUWAQFVAV-UHFFFAOYSA-N
SMILES string
O=C(C1=CC=C(CN(C2CC2)C(C3=CC4=C(NC(CO4)=O)C=C3)=O)C=C1)NC5=CC=NC=N5
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
SGC probe under development. UNC6934 is a potent and selective antagonist of histone-lysine N-methyltransferase NSD2-PWWP1 domain (Nuclear Receptor Binding SET Domain Protein 2 PWWP1 domain). UNC6934 disrupts the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells.
potent and selective antagonist of NSD2-PWWP1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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