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SML2817

BAY-1797

Name: BAY-1797
Brand: SIGMA

≥98% (HPLC), P2X4 antagonist, powder

别名:

N-(4-(3-Chlorophenoxy)-3-sulfamoylphenyl)-2-phenylacetamide, N-[3-(Aminosulfonyl)-4-(3-chlorophenoxy)phenyl]benzeneacetamide

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₇ClN₂O₄S

化学文摘社编号:

2055602-83-8

分子量:

416.88

UNSPSC Code:

51111800

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

BAY-1797, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

ClC1=CC=CC(OC2=C(C=C(NC(CC3=CC=CC=C3)=O)C=C2)S(=O)(N)=O)=C1

InChI key

CSJYMAFXYMYNCK-UHFFFAOYSA-N

说明

Biochem/physiol Actions

BAY-1797 orally available, potent and selective P2X4 antagonist that is suitable for in vivo studies in rodents. BAY-1797 exhibits potent anti-inflammatory and anti-nociceptive effects in mouse CFA inflammatory pain model.

potent and selective P2X4 antagonist

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000103936

0000103937

0000099530

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Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile.

Stefan Werner et al.

Journal of medicinal chemistry, 62(24), 11194-11217 (2019-11-21)

The P2X4 receptor is a ligand-gated ion channel that is expressed on a variety of cell types, especially those involved in inflammatory and immune processes. High-throughput screening led to a new class of P2X4 inhibitors with substantial CYP 3A4 induction

全球贸易项目编号

货号	GTIN
SML2817-25MG	04061842610792
SML2817-5MG	04061842610808