SML2821
DiFMUP
≥98% (HPLC), Fluorogenic alkaline phosphatase substrate, powder
别名:
6,8-Difluoro-4-methylumbelliferyl phosphate, 6,8-Difluoro-4-methyl-7-(phosphonooxy)-2H-1-benzopyran-2-one, 6,8-Difluoro-4-methyl-umbelliferyl phosphate, 6,8-Difluoro-4-methyl-umbelliferyl phosphate, 6,8-Difluoro-7-hydroxy-4-methylcoumarin phosphate
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关于此项目
经验公式（希尔记法）:
C10H7F2O6P
化学文摘社编号:
分子量:
292.13
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
DiFMUP, ≥98% (HPLC)
InChI
1S/C10H7F2O6P/c1-4-2-7(13)17-9-5(4)3-6(11)10(8(9)12)18-19(14,15)16/h2-3H,1H3,(H2,14,15,16)
InChI key
DZANYXOTJVLAEE-UHFFFAOYSA-N
SMILES string
CC1=CC(=O)Oc2c(F)c(OP(O)(O)=O)c(F)cc12
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
room temp
Quality Level
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Biochem/physiol Actions
DiFMUP (6,8-difluoro-4-methylumbelliferyl phosphate), a fluorinated analog of MUP, is a fluorescent synthetic substrate for continuous assessment of phosphatase activity. DiFMUP excitation/emission maxima are 358/450 nm.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Brandon S McCullough et al.
Biochemistry, 57(18), 2584-2589 (2018-04-10)
Although the importance of protein histidine phosphorylation in mammals has been a subject of increasing interest, few chemical probes are available for monitoring and manipulating PHP activity. Here, we present an optimized and validated protocol for assaying the activity of
John S Lazo et al.
The Journal of pharmacology and experimental therapeutics, 371(3), 652-662 (2019-10-12)
Oncogenic protein tyrosine phosphatases (PTPs) are overexpressed in numerous human cancers but they have been challenging pharmacological targets. The emblematic oncogenic PTP4A tyrosine phosphatase family regulates many fundamental malignant processes. 7-Imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione (JMS-053) is a novel, potent, and selective PTP4A inhibitor
Stefan Welte et al.
Analytical biochemistry, 338(1), 32-38 (2005-02-15)
The fluorogenic substrate 6,8-difluoro-4-methylumbiliferyl phosphate (DIFMUP) has been widely used for the detection of serine and threonine phosphatase activities. Here we describe the use of this substrate for the characterization of protein tyrosine phosphatases (PTPs) and for the screening for
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