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SML2821

DiFMUP

≥98% (HPLC), Fluorogenic alkaline phosphatase substrate, powder

别名:

6,8-Difluoro-4-methylumbelliferyl phosphate, 6,8-Difluoro-4-methyl-7-(phosphonooxy)-2H-1-benzopyran-2-one, 6,8-Difluoro-4-methyl-umbelliferyl phosphate, 6,8-Difluoro-4-methyl-umbelliferyl phosphate, 6,8-Difluoro-7-hydroxy-4-methylcoumarin phosphate

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关于此项目

经验公式（希尔记法）:
C10H7F2O6P
化学文摘社编号:
214491-43-7
分子量:
292.13
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
MFCD01863005
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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产品名称

DiFMUP, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

CC1=CC(=O)Oc2c(F)c(OP(O)(O)=O)c(F)cc12

InChI

1S/C10H7F2O6P/c1-4-2-7(13)17-9-5(4)3-6(11)10(8(9)12)18-19(14,15)16/h2-3H,1H3,(H2,14,15,16)

InChI key

DZANYXOTJVLAEE-UHFFFAOYSA-N

Biochem/physiol Actions

DiFMUP (6,8-difluoro-4-methylumbelliferyl phosphate), a fluorinated analog of MUP, is a fluorescent synthetic substrate for continuous assessment of phosphatase activity. DiFMUP excitation/emission maxima are 358/450 nm.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000440390
0000440389
0000440389
0000440390
0000410114

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Brandon S McCullough et al.
Biochemistry, 57(18), 2584-2589 (2018-04-10)
Although the importance of protein histidine phosphorylation in mammals has been a subject of increasing interest, few chemical probes are available for monitoring and manipulating PHP activity. Here, we present an optimized and validated protocol for assaying the activity of
Stefan Welte et al.
Analytical biochemistry, 338(1), 32-38 (2005-02-15)
The fluorogenic substrate 6,8-difluoro-4-methylumbiliferyl phosphate (DIFMUP) has been widely used for the detection of serine and threonine phosphatase activities. Here we describe the use of this substrate for the characterization of protein tyrosine phosphatases (PTPs) and for the screening for
John S Lazo et al.
The Journal of pharmacology and experimental therapeutics, 371(3), 652-662 (2019-10-12)
Oncogenic protein tyrosine phosphatases (PTPs) are overexpressed in numerous human cancers but they have been challenging pharmacological targets. The emblematic oncogenic PTP4A tyrosine phosphatase family regulates many fundamental malignant processes. 7-Imino-2-phenylthieno[3,2-c]pyridine-4,6(5H,7H)-dione (JMS-053) is a novel, potent, and selective PTP4A inhibitor

全球贸易项目编号

货号GTIN
SML2821-25MG04065266917383
SML2821-5MG04065266917390