质量水平
方案
≥98% (HPLC)
表单
powder
颜色
faint red to dark brown
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
C[N+]1=CC=CC2=C(C=CC=C12)N.[I-]
InChI
1S/C10H10N2.HI/c1-12-7-3-4-8-9(11)5-2-6-10(8)12;/h2-7,11H,1H3;1H
InChI key
JPEZFBFIRRAFNR-UHFFFAOYSA-N
生化/生理作用
5-Amino-1-methylquinolinium (5-amino-1MQ) is a substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor (IC50 = 1.2 μM; 50 μM SAM, 100 μM NCA) that reduces 3T3-L1 lipogenesis (EC50 = 30μM) and adipocytes 1-methylnicotinamide level (EC50 = 2.3 μM) without affecting related methyltransferases & enzymes in the NAD+ salvage pathway. 5-amino-1MQ shows in vivo therapeutic efficacy in murine models of DIO (20 mg/kg/d sc.), muscle injury (5 or 10 mg/kg bid. sc.), and intraperitoneal HeyA8 ovarian cancer metastasis (20 mg/kg/d ip.) with no adverse effects to the animals (up to 60 mg/kg/d). Note:1.89 mg iodide salt contains 1 mg eq of 5-amino-1MQ.
Substrate site-targeting, selective nicotinamide N-methyltransferase (NNMT) inhibitor with in vitro and in vivo efficay.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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