SML2833
JTE-607
≥98% (HPLC), cytokine release inhibitor, powder
别名:
(-)-Ethyl-N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzoyl}-L-phenylalaninate dihydrochloride, JTE 607, N-[3,5-Dichloro-2-hydroxy-4-[2-(4-methyl-1-piperazinyl)ethoxy]benzoyl]-L-phenylalanine ethyl ester dihydrochloride
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关于此项目
经验公式（希尔记法）:
C25H31Cl2N3O5·2HCl
化学文摘社编号:
分子量:
597.36
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
产品名称
JTE-607, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
Clc1c(c(cc(c1O)C(=O)N[C@@H](Cc3ccccc3)C(=O)OCC)Cl)OCCN2CCN(CC2)C.Cl.Cl
InChI
1S/C25H31Cl2N3O5.2ClH/c1-3-34-25(33)20(15-17-7-5-4-6-8-17)28-24(32)18-16-19(26)23(21(27)22(18)31)35-14-13-30-11-9-29(2)10-12-30;;/h4-8,16,20,31H,3,9-15H2,1-2H3,(H,28,32);2*1H/t20-;;/m0../s1
InChI key
JUJAUEQJEWIWCQ-FJSYBICCSA-N
Biochem/physiol Actions
JTE-607 is a pro-drug, which carboxylic form (JTE-607-COOH) is a potent cytokine release inhibitor. JTE-607 reduces the production of proinflammatory cytokines in models of acute injury, septic shock and endotoxemia. It also inhibits proliferation of AML cell in vitro and in xenograft model. JTE-607 is an inhibitor of CPSF3 (pre-messenger RNA endonuclease cleavage and polyadenylation specificity factor 3) that directly binds to CPSF3 and blocks the release of newly synthesized pre-mRNAs.
pro-drug of cytokine release inhibitor JTE-607-COOH; inhibitor of CPSF3
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable