SML2870
BI 99179
≥98% (HPLC)
别名:
(1R,3S)-3-Propionylaminocyclopentanecarboxylic acid N-[4-(benzoxazol-2-yl)phenyl]-N-methylamide, (1R,3S)-N-[4-(2-Benzoxazolyl)phenyl]-N-methyl-3-[(1-oxopropyl)amino]cyclopentanecarboxamide, BI99179
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关于此项目
经验公式（希尔记法）:
C23H25N3O3
化学文摘社编号:
分子量:
391.46
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
CCC(N[C@H]1CC[C@@H](C(N(C)C2=CC=C(C=C2)C3=NC4=C(O3)C=CC=C4)=O)C1)=O
InChI key
YNFDIGJKJPNFFD-SJORKVTESA-N
Biochem/physiol Actions
BI 99179 is a non-cytotoxic (by LDH release; 30 μM, U937) orally available, brain-penetrant, highly potent and selective fatty acid synthase (FAS, FASN) inhibitor (IC50 = 79 nM by cell-free human FAS assay) with little or no inhibitory potency toward a panel of 30 receptors & channels (<20% inhibition at 10 μM) and human CYP450 isoenzymes (1A2/2C9/2C19/2D6/3A4 IC50 >10 μM). BI 99179 inhibits cellular FAS activity in vitro (IC50 = 180 nM/human H1975, 600 nM/murine hypothalamic N-42 cells) and increases hypothalamic [malonyl-CoA] in rats in vivo (2 h post 10 mg/kg or 2-24 hr post 100 mg/kg p.o.). Note: adverse effects in rats are reported at day 4 (30 mg/kg) and day 9 (3 mg/kg).
Non-cytotoxic, orally available, brain-penetrant, highly potent and selective fatty acid synthase (FAS, FASN) inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3