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Merck
CN

SML2895

BMS-986094

≥98% (HPLC)

别名:

BMS 986094, INX-08189, N-(2′-C-Methyl-6-O-methyl-P-1-naphthalenyl-5′-guanylyl)-L-alanine 2,2-dimethylpropyl ester, Neopentyl[[[(2R,3R,4R,5R)-5-(2-amino-6-methoxy-9H-purin-9-yl)-3,4-dihydroxy-4-methyltetrahydrofuran-2-yl]methoxy](naphthalen-1-yloxy)phosphoryl]-L-alaninate

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关于此项目

经验公式（希尔记法）:
C30H39N6O9P
化学文摘社编号:
1234490-83-5
分子量:
658.64
UNSPSC Code:
51111800
NACRES:
NA.77
MDL number:
MFCD31803955
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

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产品名称

BMS-986094, ≥98% (HPLC)

SMILES string

[P](=O)(N[C@@H](C)C(=O)OCC(C)(C)C)(OC[C@H]3O[C@H]([C@@]([C@@H]3O)(O)C)[n]4c5[nH][c](nc(c5nc4)OC)=N)Oc1c2c(ccc1)cccc2

InChI

1S/C30H39N6O9P/c1-17(26(38)42-15-29(2,3)4)35-46(40,45-20-13-9-11-18-10-7-8-12-19(18)20)43-14-21-23(37)30(5,39)27(44-21)36-16-32-22-24(36)33-28(31)34-25(22)41-6/h7-13,16-17,21,23,27,37,39H,14-15H2,1-6H3,(H,35,40)(H2,31,33,34)/t17-,21+,23+,27+,30+,46?/m0/s1

InChI key

YFXGICNMLCGLHJ-RSKRLRQZSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

Quality Level

100

相关类别

Biochem/physiol Actions

BMS-986094 is an orally available prodrug of nucleotide analogue 2′-C-methylguanosine that potently inhibits Hepatitis C virus (HCV) replication. It is a guanosine nucleotide inhibitor of HCV RNA-dependent RNA polymerase NS5b.
guanosine nucleotide inhibitor of HCV RNA-dependent RNA polymerase NS5b

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number
0000119376
0000119377
0000106748

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John H Vernachio et al.
Antimicrobial agents and chemotherapy, 55(5), 1843-1851 (2011-03-02)
INX-08189 is an aryl-phosphoramidate of 6-O-methyl-2'-C-methyl guanosine. INX-08189 was highly potent in replicon assays, with a 50% effective concentration of 10±6 nM against hepatitis C genotype 1b at 72 h. The inhibitory effect on viral replication was rapid, with a
Sijia Tao et al.
Nucleosides, nucleotides & nucleic acids, 39(1-3), 204-224 (2019-10-10)
β-D-2'-C-Methyl-2,6-diaminopurine ribonucleoside (2'-C-Me-DAPN) phosphoramidate prodrug (DAPN-PD) is a selective hepatitis C virus inhibitor that is metabolized intracellularly into two active metabolites: 2'-C-Methyl-DAPN triphosphate (2'-C-Me-DAPN-TP) and 2'-C-methyl-guanosine 5'-triphosphate (2'-C-Me-GTP). BMS-986094 and IDX-184 are also bioconverted to 2'-C-Me-GTP. A phase IIb clinical
Bethany R Baumgart et al.
Toxicological sciences : an official journal of the Society of Toxicology, 153(2), 396-408 (2016-07-29)
BMS-986094, the prodrug of a guanosine nucleotide analogue (2'-C-methylguanosine), was withdrawn from clinical trials due to serious safety issues. Nonclinical investigative studies were conducted as a follow up to evaluate the potential for BMS-986094-related mitochondrial-toxicity. In vitro, BMS-986094 was applied

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