SML2901
MAC-545496
≥98% (HPLC)
别名:
N-(5-chloropyridin-2-ylcarbamothioyl)-3-nitro-4-(piperidin-1-yl)benzamide, N-[[(5-chloro-2-pyridinyl)amino]thioxomethyl]-3-nitro-4-(1-piperidinyl)benzamide
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
faint yellow to dark orange
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
S=C(Nc3ncc(cc3)Cl)NC(=O)c1cc(c(cc1)N2CCCCC2)[N+](=O)[O-]
InChI
1S/C18H18ClN5O3S/c19-13-5-7-16(20-11-13)21-18(28)22-17(25)12-4-6-14(15(10-12)24(26)27)23-8-2-1-3-9-23/h4-7,10-11H,1-3,8-9H2,(H2,20,21,22,25,28)
InChI key
AFOKREIUUQFDNW-UHFFFAOYSA-N
生化/生理作用
MAC-545496 is a potent and selective inhibitor of glycopeptide-resistance-associated protein R (GraR) that displays antivirulence and antimicrobial adjuvant properties. MAC-545496 reverses β-lactam resistance in Methicillin-resistant strains (MRSA) and synergizes with cationic antimicrobial peptides (CAMPs). It also potentiates the effects of Cefuroxime and Oxacillin MRSA strains. MAC-545496 has no effect on commensal S. epidermidis and Gram-negative bacteria such as P. aeruginosa.
potent and selective inhibitor of glycopeptide-resistance-associated protein R (GraR); antivirulent, antibacterial
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
新产品
此项目有
历史批次信息供参考:
Omar M El-Halfawy et al.
Nature chemical biology, 16(2), 143-149 (2019-11-27)
Staphylococcus aureus is the leading cause of infections worldwide, and methicillin-resistant strains (MRSA) are emerging. New strategies are urgently needed to overcome this threat. Using a cell-based screen of ~45,000 diverse synthetic compounds, we discovered a potent bioactive, MAC-545496, that
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