SML2902
LP-922056
≥98% (HPLC)
别名:
2-((6-Chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)thio)acetic acid, LP 922056
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
[s]1c2c(ncnc2SCC(=O)O)c(c1Cl)C3CC3
InChI
1S/C11H9ClN2O2S2/c12-10-7(5-1-2-5)8-9(18-10)11(14-4-13-8)17-3-6(15)16/h4-5H,1-3H2,(H,15,16)
InChI key
LJYRIWUQISYYHA-UHFFFAOYSA-N
相关类别
生化/生理作用
LP-922056 is an orally active, potent and selective NOTUM pectinacetylesterase inhibitor that activates Wnt signaling. LP-922056 stimulates endocortical bone formation in rodents and in humanized NOTUM mouse line.
orally active, potent and selective NOTUM pectinacetylesterase inhibitor that activates Wnt signaling and stimulates bone formation
储存分类代码
11 - Combustible Solids
WGK
WGK 3
James E Tarver et al.
Bioorganic & medicinal chemistry letters, 26(6), 1525-1528 (2016-02-22)
A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highly potent, orally active Notum Pectinacetylesterase inhibitors were identified.
Robert Brommage et al.
Bone research, 7, 2-2 (2019-01-10)
The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures. Cortical bone is a major determinant of non-vertebral bone strength. To identify novel osteoporosis drug
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