SML2902
LP-922056
≥98% (HPLC)
别名:
2-((6-Chloro-7-cyclopropylthieno[3,2-d]pyrimidin-4-yl)thio)acetic acid, LP 922056
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关于此项目
经验公式（希尔记法）:
C11H9ClN2O2S2
化学文摘社编号:
分子量:
300.78
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[s]1c2c(ncnc2SCC(=O)O)c(c1Cl)C3CC3
InChI
1S/C11H9ClN2O2S2/c12-10-7(5-1-2-5)8-9(18-10)11(14-4-13-8)17-3-6(15)16/h4-5H,1-3H2,(H,15,16)
InChI key
LJYRIWUQISYYHA-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
LP-922056 is an orally active, potent and selective NOTUM pectinacetylesterase inhibitor that activates Wnt signaling. LP-922056 stimulates endocortical bone formation in rodents and in humanized NOTUM mouse line.
orally active, potent and selective NOTUM pectinacetylesterase inhibitor that activates Wnt signaling and stimulates bone formation
存储类别
11 - Combustible Solids
wgk
WGK 3
James E Tarver et al.
Bioorganic & medicinal chemistry letters, 26(6), 1525-1528 (2016-02-22)
A group of small molecule thienopyrimidine inhibitors of Notum Pectinacetylesterase are described. We explored both 2-((5,6-thieno[2,3-d]pyrimidin-4-yl)thio)acetic acids and 2-((6,7-thieno[3,2-d]pyrimidin-4-yl)thio)acetic acids. In both series, highly potent, orally active Notum Pectinacetylesterase inhibitors were identified.
Robert Brommage et al.
Bone research, 7, 2-2 (2019-01-10)
The disability, mortality and costs caused by non-vertebral osteoporotic fractures are enormous. Existing osteoporosis therapies are highly effective at reducing vertebral but not non-vertebral fractures. Cortical bone is a major determinant of non-vertebral bone strength. To identify novel osteoporosis drug
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