SML2906
ERGi-USU
≥98% (HPLC)
别名:
1-[2-(2-Thiazolyl)diazenyl]-2-naphthalenol, 1-[2-Thiazolylazo]-2-naphthol, NSC139021, TAN
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
faint brown to dark red
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
[s]1c(ncc1)N=Nc2c3c(ccc2O)cccc3
InChI
1S/C13H9N3OS/c17-11-6-5-9-3-1-2-4-10(9)12(11)15-16-13-14-7-8-18-13/h1-8,17H
InChI key
IOMXCGDXEUDZAK-UHFFFAOYSA-N
相关类别
生化/生理作用
ERGi-USU is a selective and potent inhibitor of growth of ERG positive cancer cell lines, while spearing normal prostate or endothelial cells. It potently inhibits growth of ERG positive VCaP xenografts in mice. ERGi-USU is a potent and selective ligand of the ribosomal atypical kinase RIOK2 (right open reading frame (RIO) kinase 2) that induces ribosomal stress.
potent and selective ligand of the ribosomal atypical kinase RIOK2; inhibitor of growth of ERG positive cancer cell lines
储存分类代码
11 - Combustible Solids
WGK
WGK 3
法规信息
新产品
此项目有
历史批次信息供参考:
Ahmed A Mohamed et al.
Cancer research, 78(13), 3659-3671 (2018-05-02)
Oncogenic activation of the ETS-related gene (ERG) by recurrent gene fusions (predominantly TMPRSS2-ERG) is one of the most validated and prevalent genomic alterations present in early stages of prostate cancer. In this study, we screened small-molecule libraries for inhibition of
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