SML2909
Nolatrexed dihydrochloride
≥98% (HPLC)
别名:
2-Amino-6-methyl-5-(4-pyridinylthio)-4(1H)-quinazolinone dihydrochloride, AG 337
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关于此项目
经验公式（希尔记法）:
C14H12N4OS · 2HCl
化学文摘社编号:
分子量:
357.26
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to beige
溶解性
H2O: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
NC1=NC(C2=C(N1)C=CC(C)=C2SC3=CC=NC=C3)=O
InChI
1S/C14H12N4OS.2ClH/c1-8-2-3-10-11(13(19)18-14(15)17-10)12(8)20-9-4-6-16-7-5-9;;/h2-7H,1H3,(H3,15,17,18,19);2*1H
InChI key
PJKVJJYMWOCLIJ-UHFFFAOYSA-N
相关类别
生化/生理作用
Nolatrexed dihydrochloride is a water-soluble lipophilic quinazoline folate analog that exhibits potent antineoplastic activity. Nolatrexed is a potent thymidylate synthase inhibitor that inhibits thymine synthesis followed by inhibition of DNA replication.
potent thymidylate synthase inhibitor
警示用语：
Warning
危险声明
危险分类
Muta. 2 - Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
A N Hughes et al.
British journal of cancer, 82(9), 1519-1527 (2000-05-02)
A clinical study of nolatrexed dihydrochloride (AG337, Thymitaq) in combination with paclitaxel was performed. The aims were to optimize the schedule of administration and determine any pharmacokinetic (PK) interactions between the two drugs. In vitro combination studies were performed to
Simon Dewar et al.
The Journal of biological chemistry, 291(47), 24768-24778 (2016-10-21)
The aim of this study was to identify and characterize mechanisms of resistance to antifolate drugs in African trypanosomes. Genome-wide RNAi library screens were undertaken in bloodstream form Trypanosoma brucei exposed to the antifolates methotrexate and raltitrexed. In conjunction with
Dan Chen et al.
The Journal of biological chemistry, 292(32), 13449-13458 (2017-06-22)
Thymidylate synthase (TS) is the sole enzyme responsible for de novo biosynthesis of thymidylate (TMP) and is essential for cell proliferation and survival. Inhibition of human TS (hTS) has been extensively investigated for cancer chemotherapy, but several aspects of its
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