SML2918
INT131
≥98% (HPLC)
别名:
2,4-Dichloro-N-[3,5-dichloro-4-(3-quinolinyloxy)phenyl]benzenesulfonamide, AMG-131, T0903131
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关于此项目
经验公式（希尔记法）:
C21H12Cl4N2O3S
化学文摘社编号:
分子量:
514.21
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(Nc2cc(c(c(c2)Cl)Oc3cnc4c(c3)cccc4)Cl)c1c(cc(cc1)Cl)Cl
InChI
1S/C21H12Cl4N2O3S/c22-13-5-6-20(16(23)8-13)31(28,29)27-14-9-17(24)21(18(25)10-14)30-15-7-12-3-1-2-4-19(12)26-11-15/h1-11,27H
InChI key
NMRWDFUZLLQSBN-UHFFFAOYSA-N
Biochem/physiol Actions
INT131 is a brain penetrant, non-thiazolidinedione, highly potent and selective peroxisome proliferator-activated receptor gamma (PPARγ) modulator (SPPARM) that displays anti-diabetic activities. INT131 is a partial, rather than a full agonist of PPARγ, and in clinical trials has shown increased glucose tolerance without the weight gain and cardiovascular side effects seen with some of the full agonist.
Selective PPAR Modulator (SPPARM)
存储类别
11 - Combustible Solids
法规信息
新产品
此项目有
Xinni Xie et al.
Frontiers in pharmacology, 8, 317-317 (2017-06-15)
The mechanisms underlying the enhancement of insulin sensitivity by selective peroxisome proliferator-activated receptor γ modulators (sPPARγMs) are still not completely known. Here, the representative sPPARγM, INT131, was used as a probe to investigate the insulin-sensitizing mechanisms of sPPARγM in the
INT131: a selective modulator of PPAR gamma
Motani A, Wang Z, Weiszmann J, McGee LR, Lee G, Liu Q, Staunton J, Fang Z, Fuentes H, et al
Journal of Molecular Biology, 386, 1301-1311 (2009)
Amila Omeragic et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 1996-2010 (2020-01-08)
Despite the use of antiretroviral therapy for the treatment of HIV-1 infection, cognitive impairments, that is, HIV-1-associated neurocognitive disorders remain prevalent potentially due to persistent viral replication, production of viral proteins, associated brain inflammation or in certain instances, antiretroviral neurotoxicity.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML2918-5MG | 04061842701742 |
| SML2918-25MG | 04061842701735 |