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Merck
CN

SML2922

Sigma-Aldrich

SEW84

≥98% (HPLC)

别名:

1-(4-Fluorophenyl)-1H-pyrrole-2-carboxylic acid 2-[thioxo[[3-(trifluoromethylphenyl]-amino]methyl]hydrazide

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关于此项目

经验公式(希尔记法):
C19H14F4N4OS
化学文摘社编号:
分子量:
422.40
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
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质量水平

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

2-8°C

SMILES字符串

FC(F)(F)c1cc(ccc1)NC(=S)NNC(=O)c2[n](ccc2)c3ccc(cc3)F

InChI

1S/C19H14F4N4OS/c20-13-6-8-15(9-7-13)27-10-2-5-16(27)17(28)25-26-18(29)24-14-4-1-3-12(11-14)19(21,22)23/h1-11H,(H,25,28)(H2,24,26,29)

InChI key

QEJONNSHVNSZBJ-UHFFFAOYSA-N

生化/生理作用

SEW84 is a potent and selective inhibitor of the Aha1-stimulated Hsp90 ATPase activity without inhibition of basal Hsp90 ATPase. It binds to the C-terminal domain of Aha1 and weakens the Hsp90-Aha1 interaction. SEW84 inhibits Aha1-dependent Hsp90 chaperoning activities including refolding of denatured firefly luciferase (in vitro) and in vivo transcriptional activity of the glucocorticoid receptor and AR androgen receptor in prostate cancer cell-based models. SEW84 preferentially clears Alzheimer disease related phosphorylated aggregation-prone Tau in primary rat cortical neurons.
potent and selective inhibitor of the Aha1-stimulated Hsp90 ATPase activity

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Jay K Singh et al.
Cell chemical biology, 27(3), 292-305 (2020-02-06)
Hsp90 plays an important role in health and is a therapeutic target for managing misfolding disease. Compounds that disrupt co-chaperone delivery of clients to Hsp90 target a subset of Hsp90 activities, thereby minimizing the toxicity of pan-Hsp90 inhibitors. Here, we

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