SML2939
S2C3 Dibromide
≥98% (HPLC)
别名:
CYDE-21 dibromide, N,N′-(Decane-1,10-diyl)bis(9-amino-2,3-dihydro-1H-cyclopenta[b]quinolinium) dibromide
InChI
1S/C34H42N4/c35-33-25-15-7-9-19-29(25)37(31-21-13-17-27(31)33)23-11-5-3-1-2-4-6-12-24-38-30-20-10-8-16-26(30)34(36)28-18-14-22-32(28)38/h7-10,15-16,19-20,35-36H,1-6,11-14,17-18,21-24H2/p+2
InChI key
MEFIQYBUDHNVHT-UHFFFAOYSA-P
SMILES string
NC1=C2C=CC=CC2=[N+](C3=C1CCC3)CCCCCCCCCC[N+]4=C5CCCC5=C(C6=C4C=CC=C6)N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (Warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
HIV-1 fusion inhibitor that specifically binds to the gp41 membrane proximal external region (MPER)
S2C3, an analog of dequalinium, is an HIV-1 fusion inhibitor that specifically binds to the gp41 membrane proximal external region (MPER) of the HIV-1 envelope spike and blocks CD4-induced conformational changes. S2C3 effectively block HIV-1 infection. S2C3 (CYDE-21) is a cationic amphiphilic bolaamphiphile nano-sized vesicles or vesicle-like aggregates suitable to carry antisense oligonucleotides (ASO) into bacterium such as C. difficile.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes
Nature Chemical Biology, 16 (2020)
Cationic amphiphilic bolaamphiphile-based delivery of antisense oligonucleotides provides a potentially microbiome sparing treatment for C. difficile
The Journal of Antibiotics, 71 (2018)
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