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SML2948

Mca-APK(Dnp)-OH trifluoroacetate

Name: Mca-APK(Dnp)-OH trifluoroacetate
Brand: SIGMA

≥97% (HPLC), ACE2 substrate, film or powder

别名:

Mca-APK(Dnp) TFA salt (Mca = 7-Methoxycoumarin-4-yl; Dnp = 2,4-dinitrophenyl), Mca-Ala-Pro-Lys(Dnp) TFA salt, Mca-Ala-Pro-Lys(Dnp)-OH TFA salt

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关于此项目

经验公式（希尔记法）:

C₃₂H₃₆N₆O₁₂ · xC₂HF₃O₂

分子量:

696.66 (free base basis)

UNSPSC Code:

12352200

NACRES:

NA.77

Assay:

≥97% (HPLC)

Form:

film or powder

Quality level:

100

Storage condition:

desiccated

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属性

产品名称

Mca-APK(Dnp)-OH trifluoroacetate, ≥97% (HPLC)

Quality Level

100

assay

≥97% (HPLC)

form

film or powder

storage condition

desiccated

color

white to dark beige

storage temp.

−20°C

说明

Biochem/physiol Actions

Mca-APK(Dnp)-OH is a widely used fluorescent substrate for angiotensin-converting enzyme 2 (ACE2 cleaves between P & K). Proteolytic cleavage separates 7-methoxycoumarin-4-acetyl (Mca) from the fluorescence-quenching group 2,4-dinitrophenyl (Dnp), resulting in increased Mca fluorescence (Ex: 320-328 nm, Em: 405-420 nm). The fluorescence increase over background upon Mca-APK(Dnp) cleavage is more than 14-fold higher than that of Mca-YVADAPK(Dnp), while only Mca-YVADAPK(Dnp), but not Mca-APK(Dnp), can also be used for assessing caspase-1 (ICE) activity.

Popular fluorescent substrate for angiotensin-converting enzyme 2 (ACE2).

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

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历史批次信息供参考:

分析证书(COA)

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Chintan K Gandhi et al.

Lung, 197(2), 227-233 (2019-02-14)

Pancreatic digestive enzymes present in meconium might be responsible for meconium-induced lung injury. The local Renin Angiotensin System plays an important role in lung injury and inflammation. Particularly, angiotensin converting enzyme-2 (ACE-2) has been identified as a protective lung enzyme against

Both aldosterone and spironolactone can modulate the intracellular ACE/ANG II/AT1 and ACE2/ANG (1-7)/MAS receptor axes in human mesangial cells.

Danielle Stoll et al.

Physiological reports, 7(11), e14105-e14105 (2019-06-06)

The kidney is an important target of the renin-ANG-aldosterone system (RAAS). To date, several studies have demonstrated the existence of a local RAAS in various tissues, including the renal tissue. The mineralocorticoid aldosterone is known to play a critical role

Angiotensin-converting enzyme 2 regulates autophagy in acute lung injury through AMPK/mTOR signaling.

Xiaomiao Zhang et al.

Archives of biochemistry and biophysics, 672, 108061-108061 (2019-07-30)

Autophagy exerts a dual role in promoting cell death or survival. Recent studies have shown that it may play an important role in lipopolysaccharide (LPS)-induced acute lung injury (ALI). It was also suggested that angiotensin converting enzyme 2 (ACE2) may

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全球贸易项目编号

货号	GTIN
SML2948-1MG	04065265137096
SML2948-5MG	04065265137102