SML2980
G6PDi-1
≥98% (HPLC), G6PD inhibitor, powder
别名:
4-([5-oxo-6H,7H,8H,9H-cyclohepta[d]pyrimidin-2-yl]amino)thiophene-2-carbonitrile
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选择尺寸
关于此项目
经验公式（希尔记法）:
C14H12N4OS
化学文摘社编号:
分子量:
284.34
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
产品名称
G6PDi-1, ≥98% (HPLC)
InChI
1S/C14H12N4OS/c15-6-10-5-9(8-20-10)17-14-16-7-11-12(18-14)3-1-2-4-13(11)19/h5,7-8H,1-4H2,(H,16,17,18)
InChI key
USWCHVCZOGGQQA-UHFFFAOYSA-N
SMILES string
N#CC1=CC(NC2=NC=C3C(CCCCC3=N2)=O)=CS1
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
G6PDi-1 is a cell penetrant potent and selective nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD). G6PDi-1 strongly depletes NADPH in lymphocytes. It decreases inflammatory cytokine response in macrophages, and suppresses respiratory burst in neutrophils.
cell penetrant potent and selective nonsteroidal inhibitor of glucose-6-phosphate dehydrogenase (G6PD)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jonathan M Ghergurovich et al.
Nature chemical biology, 16(7), 731-739 (2020-05-13)
Glucose is catabolized by two fundamental pathways, glycolysis to make ATP and the oxidative pentose phosphate pathway to make reduced nicotinamide adenine dinucleotide phosphate (NADPH). The first step of the oxidative pentose phosphate pathway is catalyzed by the enzyme glucose-6-phosphate
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