SML2986
NSC 15520
≥98% (HPLC)
别名:
15-Carboxy-13-isopropylatis-13-ene-17,18-dioic acid, NSC15520
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关于此项目
经验公式（希尔记法）:
C24H34O6
化学文摘社编号:
分子量:
418.52
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
[P](=O)(OCC\C(=C(/N(Cc2c(nc(nc2)C)N)C=O)\C)\SC(=O)c1ccccc1)(O)O
InChI
1S/C19H23N4O6PS/c1-13(23(12-24)11-16-10-21-14(2)22-18(16)20)17(8-9-29-30(26,27)28)31-19(25)15-6-4-3-5-7-15/h3-7,10,12H,8-9,11H2,1-2H3,(H2,20,21,22)(H2,26,27,28)/b17-13+
InChI key
BTNNPSLJPBRMLZ-GHRIWEEISA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Inhibitor of the RPA70 N-terminal protein interaction domain
NSC15520 is an inhibitor of the N-terminal protein interaction domain of Replication Protein A (RPA), the major single-stranded DNA binding protein in eukaryotes, which is required for DNA replication, DNA repair, DNA recombination, and DNA damage response signaling. It has been shown to block the association of RPA to p53 and RAD9. In pluripotent stem cells, NSC 15520 increased targeted nucleotide substitutions in CRISPER reactions using Cas9n and Cpf1. It has been used along with a group of other small molecules to achieve a 2.8 to 7.2-fold increase in precision gene editing with Cas9.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jason G Glanzer et al.
Bioorganic & medicinal chemistry, 19(8), 2589-2595 (2011-04-05)
The pharmacological suppression of the DNA damage response and DNA repair can increase the therapeutic indices of conventional chemotherapeutics. Replication Protein A (RPA), the major single-stranded DNA binding protein in eukaryotes, is required for DNA replication, DNA repair, DNA recombination
Stephan Riesenberg et al.
Nature communications, 9(1), 2164-2164 (2018-06-06)
A now frequently used method to edit mammalian genomes uses the nucleases CRISPR/Cas9 and CRISPR/Cpf1 or the nickase CRISPR/Cas9n to introduce double-strand breaks which are then repaired by homology-directed repair using DNA donor molecules carrying desired mutations. Using a mixture
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