SML2990
dCeMM2
≥98% (HPLC)
别名:
2-((5H-[1,2,4]Triazino[5,6-b]indol-3-yl)thio)-N-(5-chloropyridin-2-yl)acetamide, N-(5-Chloro-2-pyridinyl)-2-(5H-1,2,4-triazino[5,6-b]indol-3-ylthio)acetamide
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关于此项目
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
O=C(NC1=NC=C(Cl)C=C1)CSC2=NC3=C(C4=C(N3)C=CC=C4)N=N2
InChI
1S/C16H11ClN6OS/c17-9-5-6-12(18-7-9)20-13(24)8-25-16-21-15-14(22-23-16)10-3-1-2-4-11(10)19-15/h1-7H,8H2,(H,18,20,24)(H,19,21,23)
InChI key
VFWVTIHYVUKNGR-UHFFFAOYSA-N
Biochem/physiol Actions
cell penetrant molecular glue degrader that induce ubiquitination and degradation of cyclin K by inciting an interaction of CDK12–cyclin K with a CRL4B ligase
dCeMM2 is a cell penetrant molecular glue degrader that induce ubiquitination and degradation of cyclin K by inciting an interaction of CDK12–cyclin K with a CRL4B ligase complex. dCeMM2 induced proximity between CDK12–cyclin K and the CRL complex adaptor protein DDB1 that causes ubiquitination and proteasomal degradation of cyclin K.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Cristina Mayor-Ruiz et al.
Nature chemical biology, 16(11), 1199-1207 (2020-08-05)
Targeted protein degradation is a new therapeutic modality based on drugs that destabilize proteins by inducing their proximity to E3 ubiquitin ligases. Of particular interest are molecular glues that can degrade otherwise unligandable proteins by orchestrating direct interactions between target
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML2990-5MG | 04065265015226 |
| SML2990-25MG | 04065265015219 |
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