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Merck
CN

SML2998

Sigma-Aldrich

莫昔克丁

≥98% (HPLC)

别名:

Moxidectin, (6R,23E,25S)-5-O-Demethyl-28-deoxy-25-[(1E)-1,3-dimethyl-1-buten-1-yl]-6,28-epoxy-23-(methoxyimino)milbemycin B, 23-Methoxime-LL-F 28249α, CL 301,423, CL 301423, CL301,423, CL301423, Equest, ProHeart 6

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关于此项目

经验公式（希尔记法）:
C37H53NO8
化学文摘社编号:
113507-06-5
分子量:
639.82
MDL编号:
MFCD00866560
UNSPSC代码:
12352119
NACRES:
NA.77

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质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to beige

溶解性

DMSO: 2 mg/mL, clear

储存温度

−20°C

SMILES字符串

CO\N=C1/C[C@]2(C[C@@H]3CC(C\C=C(C)\C[C@@H](C)\C=C\C=C4/COC5[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]45O)O2)O[C@@H]([C@H]1C)\C(C)=C\C(C)C

InChI

1S/C37H53NO8/c1-21(2)14-25(6)33-26(7)31(38-42-8)19-36(46-33)18-29-17-28(45-36)13-12-23(4)15-22(3)10-9-11-27-20-43-34-32(39)24(5)16-30(35(40)44-29)37(27,34)41/h9-12,14,16,21-22,26,28-30,32-34,39,41H,13,15,17-20H2,1-8H3/b10-9+,23-12+,25-14+,27-11+,38-31+/t22-,26-,28+,29-,30-,32+,33+,34+,36-,37+/m0/s1

InChI key

YZBLFMPOMVTDJY-LSGXYNIPSA-N

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生化/生理作用

Moxidectin is an orally active antihelminthic (antiparasitic) that targets parasite glutamate-gated chloride ion channels (GluCls). Moxidectin binding increases target GluCl permeability, resulting in influx of chloride ions and dysfunction of the excretory pore, flaccid paralysis, and death of the parasite through host response.

象形图

Skull and crossbonesEnvironment
GHS06,GHS09

警示用语：

Danger

危险声明

H301,H400

危险分类

Acute Tox. 3 Oral - Aquatic Acute 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000270358
0000270358
0000272732
0000272732
0000126578

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Valentin Buchter et al.
ACS infectious diseases, 7(5), 1069-1076 (2020-09-30)
Strongyloides stercoralis is a soil-transmitted helminth affecting an estimated 30-100 million people. Since the infection may be severe and life-threatening, accessible and effective treatment is pivotal. Currently, ivermectin is the drug of choice but has limitations. Moxidectin, a veterinary anthelminthic
Raj Packianathan et al.
Parasites & vectors, 13(1), 448-448 (2020-09-07)
The Australian paralysis tick, Ixodes holocyclus, causes tick paralysis in dogs and cats in the eastern coastal regions of Australia. Prevention is the best option to protect dogs against this potentially fatal disease and sarolaner provides rapid and sustained efficacy
Molly D Savadelis et al.
Journal of veterinary internal medicine, 34(5), 1734-1745 (2020-07-22)
Administration of moxidectin topically and doxycycline PO has been utilized experimentally as an alternative treatment for heartworm disease. However, clinical effects of this protocol remain poorly characterized. To evaluate the clinical and postmortem findings associated with administration of doxycycline and
Csilla Becskei et al.
Parasites & vectors, 13(1), 385-385 (2020-07-31)
Infection with the cardiopulmonary nematode Angiostrongylus vasorum may cause severe disease in dogs, therefore prophylactic treatments are necessary to prevent infection in dogs at risk. A clinical field study was conducted to demonstrate the efficacy and safety of an oral
Wieland Beck
Veterinary parasitology, 283, 109190-109190 (2020-08-02)
An outbreak of sarcoptic mange was investigated in a herd of llamas and alpacas in the Black Forrest (Baden-Wuerttemberg, Germany). The diagnosis was made by clinical picture and detection of mites in skin scrapings and ear swabs. At the beginning
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