SML3014
KL101
≥98% (HPLC)
别名:
N-(2-(2,4-Dimethylphenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-yl)-3,4-dimethyl-benzamide
InChI
1S/C22H23N3OS/c1-13-5-8-20(16(4)9-13)25-21(18-11-27-12-19(18)24-25)23-22(26)17-7-6-14(2)15(3)10-17/h5-10H,11-12H2,1-4H3,(H,23,26)
InChI key
FJKKXWLUKJOWNU-UHFFFAOYSA-N
SMILES string
CC1=CC=C(C(NC2=C(CSC3)C3=NN2C4=C(C)C=C(C)C=C4)=O)C=C1C
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
KL101 is a circadian clock modulator that lengthens a circadian period in cells and tissues. It selectively stabilizes CRY1 through interaction with FAD-binding pocket. KL101 strongly enhanced brown adipocyte differentiation in culture. KL101 showed no or only minor effects on CKIδ, CKIα and CK2 activities in vitro.
circadian clock modulator that selectively stabilizes CRY1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Simon Miller et al.
Nature chemical biology, 16(6), 676-685 (2020-04-02)
CRY1 and CRY2 are essential components of the circadian clock controlling daily physiological rhythms. Accumulating evidences indicate distinct roles of these highly homologous proteins, in addition to redundant functions. Therefore, the development of isoform-selective compounds represents an effective approach towards
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