SML3016
Afobazole
≥98% (HPLC)
别名:
2-((2-Morpholino)ethylthio)-5-ethoxybenzimidazole, 5-Ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]-1H-benzimidazole, 6-Ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]-1H-benzimidazole, Afobazol, Aphobazole, CM 346, Fabomotizole
质量水平
方案
≥98% (HPLC)
表单
film
颜色
white to beige
储存温度
2-8°C
SMILES字符串
CCOC1=CC2=C(C=C1)N=C(SCCN3CCOCC3)N2
InChI
1S/C15H21N3O2S/c1-2-20-12-3-4-13-14(11-12)17-15(16-13)21-10-7-18-5-8-19-9-6-18/h3-4,11H,2,5-10H2,1H3,(H,16,17)
InChI key
WWNUCVSRRUDYPP-UHFFFAOYSA-N
生化/生理作用
Afobazole is an anxiolytic that appears to act via σ-1 and σ2 receptors. Afobazole exhibit neuroprotective potential in both in vivo and in vitro models. It is a potent modulator of microglia.
anxiolytic that appears to act via σ-1 and σ-2 receptors
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
Javier Cuevas et al.
The Journal of pharmacology and experimental therapeutics, 339(1), 161-172 (2011-07-01)
Microglial cells play a critical role in the neuroinflammatory response that accompanies various diseases of the central nervous system, such as ischemic stroke, and ATP is a major signaling molecule regulating the response of these cells to these pathophysiological conditions.
Mikhail V Voronin et al.
Pharmacology research & perspectives, 4(6), e00273-e00273 (2017-01-18)
Anxiolytic afobazole (5-Ethoxy-2-[2-(morpholino)-ethylthio]benzimidazole dihidrochloride) has pronounced ligand properties toward Sigma-1 receptor (σ1 receptor,SigmaR1) and MT 3 receptors. Our previous work demonstrated that afobazole possess cytoprotective effect in the in vitro model of menadione genotoxicity (Woods et al. 1997) through interaction with MT
Javier Cuevas et al.
The Journal of pharmacology and experimental therapeutics, 339(1), 152-160 (2011-07-01)
Afobazole is an anxiolytic medication that has been previously shown to be neuroprotective both in vitro and in vivo. However, the mechanism(s) by which afobazole can enhance neuronal survival remain poorly understood. Experiments were carried out to determine whether afobazole
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