SML3035
Ziprasidone hydrochloride hydrate
≥97% (HPLC)
别名:
5-[2-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]ethyl]-6-chloro-1,3-dihydro-2H-indol-2-one hydrochloride hydrate, CP-88,059, CP-88,059-01, CP-88059
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关于此项目
经验公式（希尔记法）:
C21H21ClN4OS · xHCl · yH2O
化学文摘社编号:
分子量:
412.94 (anhydrous free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
InChI
1S/C21H21ClN4OS/c22-17-13-18-15(12-20(27)23-18)11-14(17)5-6-25-7-9-26(10-8-25)21-16-3-1-2-4-19(16)28-24-21/h1-4,11,13H,5-10,12H2,(H,23,27)
InChI key
MVWVFYHBGMAFLY-UHFFFAOYSA-N
SMILES string
O=C1CC(C=C(C(Cl)=C2)CCN3CCN(CC3)C4=NSC5=C4C=CC=C5)=C2N1.[xHCl].[yH2O]
assay
≥97% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
solubility
DMSO: 2 mg/mL, clear
Quality Level
Biochem/physiol Actions
Atypical antipsychotic with 5HT1A agonist, as well as D2, 5HT2A, and 5HT1D antagonist activity.
Ziprasidone is an atypical antipsychotic with 5HT1A agonist, as well as D2, 5HT2A, and 5HT1D antagonist activity.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1 - STOT RE 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
T F Seeger et al.
The Journal of pharmacology and experimental therapeutics, 275(1), 101-113 (1995-10-01)
Ziprasidone (CP-88,059) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects in preclinical assays predictive of antipsychotic activity. Whereas the compound is a dopamine antagonist in vitro and in vivo, its most potent action is antagonism
C J Bench et al.
Psychopharmacology, 124(1-2), 141-147 (1996-03-01)
Positron emission tomography (PET) and 11C-raclopride were used to assess the time course of binding to central dopamine D2 receptors by the novel neuroleptic ziprasidone. In a third party blind study, six healthy male control subjects received a predose of
C Prakash et al.
Drug metabolism and disposition: the biological fate of chemicals, 25(2), 206-218 (1997-02-01)
The metabolism and excretion of ziprasidone (5-[2-[4-(1,2-benzisothiazol-3-yl)piperazin-1-yl]ethyl]-6-++ +chloroindolin-2-one hydrochloride hydrate) were studied in Long Evans rats after oral administration of a single dose of a mixture of 14C- and 3H-labeled ziprasidone. The radioactive dose was quantitatively recovered over 7 days
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