Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
COc1ccc2C[C@@H]3N(C)CCc4cc(OC)c(OC)c(Oc5cc6[C@H](Cc7ccc(Oc1c2)cc7)N(C)CCc6cc5OC)c34
InChI
1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30-/m0/s1
InChI key
WVTKBKWTSCPRNU-KYJUHHDHSA-N
Biochem/physiol Actions
Tetrandrine is bisbenzylisoquinoline alkaloid extracted from isolated from Stephania tetrandra S Moore that exhibits numerous pharmacological activities including anti-cancer, anti-inflammatory, negative ionotropic and chronotropic effects on myocardium, immunologic and antiallergenic effects. It has been used for treatment of tuberculosis, hyperglycemia, malaria, cancer and fever. Tetrandrine is potent calcium channel blocker. Tetrandrine targets multiple signaling pathways controlling cell cycle, apoptosis. Tetrandrine is an inhibitor of efflux pumps that reversed the clarithromycin resistance phenotype of some Mycobacterium avium complex clinical isolates.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable