SML3050
Olsalazine sodium
别名:
Olsalazine sodium, 3,3´-Azobis(6-hydroxybenzoic acid) sodium, 5,5′-Azodisalicylic acid sodium, 5,5′-azobis(salicylic acid) sodium, C.I. Mordant Yellow 5; 3,3′-dicarboxy-4,4′-dihydroxyazobenzene sodium, azodisal sodium
SMILES string
[Na+].[Na+].N(=N\c2cc(c(cc2)[O-])C(=O)O)/c1cc(c(cc1)[O-])C(=O)O
InChI key
ZJEFYLVGGFISGT-VRZXRVJBSA-L
InChI
1S/C14H10N2O6.2Na/c17-11-3-1-7(5-9(11)13(19)20)15-16-8-2-4-12(18)10(6-8)14(21)22;;/h1-6,17-18H,(H,19,20)(H,21,22);;/q;2*+1/p-2/b16-15+;;
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
H2O: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Olsalazine is an anti-inflammatory drug used in inflammatory bowel disease and ulcerative colitis treatments. It is a pro-drug of 5-aminosalicylic acid (mesalamine) that it is converted by the bacteria in the colon to mesalamine. Olsalazine (5-aminosalicylic acid) is consider as a broad-spectrum anticancer agent. Additionally, olsalazine increases both eEF1A2 and utrophin A levels in in C2C12 myoblasts (relevant to Duchenne muscular dystrophy).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Sandra Cortez-Maya et al.
Biomolecules, 9(8) (2019-08-16)
Improving the activity and selectivity profile of anticancer agents will require designing drug carrier systems that employ soluble macromolecules. Olsalazine-PAMAM-dendrimer-salicylic acid-conjugates with dendritic arms of different lengths have shown good stability regarding the chemical link between drug and spacer. In
Amany A Abdin et al.
Journal of Crohn's & colitis, 2(4), 296-303 (2008-12-01)
Traditional medical treatments for ulcerative colitis (UC) are still compromised by its adverse effects and not potent enough to keep in remission for long-term periods. So, new therapies that are targeted at specific disease mechanisms have the potential to provide
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