SML3052
ppTG21 trifluoroacetate salt
≥95% (HPLC)
别名:
GLFHALLHLLHSLWHLLLHA-OH TFA salt, Gly-Leu-Phe-His-Ala-Leu-Leu-His-Leu-Leu-His-Ser-Leu-Trp-His-Leu-Leu-Leu-His-Ala TFA salt
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关于此项目
经验公式（希尔记法）:
C115H173N31O22 · xC2HF3O2
分子量:
2341.80 (free base basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Biochem/physiol Actions
Endosomolytic agent that facilitates cell type-specific gene editing by enabling Cas9 RNP endosome escape following receptor-mediated endocytosis.
ppTG21 is an endosomolytic agent (pI 7.7, charge +1.3 @ pH 7.4) that facilitates cell type-specific gene editing by enabling endosome escape of Cas9 ribonucleoprotein (RNP) complex following its uptake via receptor-mediated endocytosis. Following liver-specific asialoglycoprotein receptor (ASGPr)-mediated delivery of ASGPr ligand (ASGPrL)-harboring & SV40 nuclear localization sequence (NLS)-bearing S. pyogenes Cas9 (Cas9-2lig-1NLS) RNP with EMX1-targeting sgRNA, target gene editing occurs only upon coincubation of the RNP in the presence of 30 molar equiv of ppTG21 (ave 4.8% indels in HepG2 cells vs. 0.2% indels without ppTG21).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
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Journal of the American Chemical Society, 140(21), 6596-6603 (2018-04-19)
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Karola Rittner et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 5(2), 104-114 (2002-02-07)
We have designed new basic amphiphilic peptides, ppTG1 and ppTG20 (20 amino acids), and evaluated their efficiencies in vitro and in vivo as single-component gene transfer vectors. ppTG1 and ppTG20 bind to nucleic acids and destabilize liposomes consisting of 1-palmitoyl-2-oleoylphosphatidylcholine
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