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SML3060

Panobinostat

Name: Panobinostat
Brand: SIGMA

≥98% (HPLC), Pan-histone deacetylase inhibitor, powder

别名:

(2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide, LBH 589, LBH-589, LBH589, N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)-ethyl]-amino]methyl]phenyl]-2E-2-propenamide, NVP-LBH589

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₃N₃O₂

化学文摘社编号:

404950-80-7

分子量:

349.43

NACRES:

NA.77

UNSPSC Code:

12352200

MDL number:

MFCD09833242

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

Panobinostat, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

2-8°C

SMILES string

CC1=C(CCNCC2=CC=C(/C=C/C(NO)=O)C=C2)C3=CC=CC=C3N1

InChI

1S/C21H23N3O2/c1-15-18(19-4-2-3-5-20(19)23-15)12-13-22-14-17-8-6-16(7-9-17)10-11-21(25)24-26/h2-11,22-23,26H,12-14H2,1H3,(H,24,25)/b11-10+

InChI key

FPOHNWQLNRZRFC-ZHACJKMWSA-N

说明

Biochem/physiol Actions

Orally active, potent, cinnamoyl hydroxamate-type pan-histone deacetylase inhibitor with anti-cancer efficacy in vitro and in vivo.

Panobinostat (LBH589) is an orally active, potent, cinnamoyl hydroxamate-type pan-histone deacetylase inhibitor (class I HDAC1/2/3/8 IC50 = 2.5/13.2/2.1/277 nM; IIA HDAC4/5/7/9 IC50 = 203/7.8/531/5.7 nM; IIB HDAC6/10 IC50 = 10.5/2.3 nM, IV HDAC11 IC50 = 2.7 nM) with anti-cancer efficacy in vitro and in vivo.

pictograms

GHS06,GHS08,GHS05

signalword

Danger

hcodes

H301 + H331,H315,H318,H360,H373

pcodes

P202 - P280 - P301 + P310 - P302 + P352 - P304 + P340 + P311 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Dam. 1 - Repr. 1B - Skin Irrit. 2 - STOT RE 2 Inhalation

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Histone deacetylase inhibition enhances the therapeutic effects of methotrexate on primary central nervous system lymphoma.

Kenji Fujimoto et al.

Neuro-oncology advances, 2(1), vdaa084-vdaa084 (2020-08-15)

Polyglutamylation is a reversible protein modification that commonly occurs in tumor cells. Methotrexate (MTX) in tumor cells is polyglutamylated and strongly binds to dihydrofolate reductase (DHFR) without competitive inhibition by leucovorin. Therefore, tumor cells with high polyglutamylation levels are supposed

Antifungal Activity and Potential Mechanism of Panobinostat in Combination With Fluconazole Against Candida albicans.

Shan Su et al.

Frontiers in microbiology, 11, 1584-1584 (2020-08-09)

Invasive fungal infections are an emerging problem worldwide, which bring huge health challenges. Candida albicans, the most common opportunistic fungal pathogen, can cause bloodstream infections with high mortality in susceptible hosts. At present, available antifungal agents used in clinical practice

High-dose MTX110 (soluble panobinostat) safely administered into the fourth ventricle in a nonhuman primate model.

David I Sandberg et al.

Journal of neurosurgery. Pediatrics, 1-9 (2020-05-02)

Chemotherapy infusions directly into the fourth ventricle may play a role in treating malignant fourth-ventricular tumors. This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma) into the fourth ventricle of nonhuman

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全球贸易项目编号

货号	GTIN
SML3060-10MG	04065266275001
SML3060-50MG	04065266275018