SML3092
CHIR-090
≥98% (HPLC), LpxC inhibitor, powder
别名:
CHIR 090, CHIR090, N-((2S,3R)-3-Hydroxy-1-(hydroxyamino)-1-oxobutan-2-yl)-4-((4-(morpholinomethyl)phenyl)ethynyl)benzamide, N-[(1S,2R)-2-Hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[2-[4-(4-morpholinylmethyl)phenyl]ethynyl]benzamide
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关于此项目
经验公式（希尔记法）:
C24H27N3O5
化学文摘社编号:
分子量:
437.49
NACRES:
NA.77
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
产品名称
CHIR-090, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
C[C@H]([C@@H](C(NO)=O)NC(C1=CC=C(C=C1)C#CC2=CC=C(C=C2)CN3CCOCC3)=O)O
InChI
1S/C24H27N3O5/c1-17(28)22(24(30)26-31)25-23(29)21-10-8-19(9-11-21)3-2-18-4-6-20(7-5-18)16-27-12-14-32-15-13-27/h4-11,17,22,28,31H,12-16H2,1H3,(H,25,29)(H,26,30)/t17-,22+/m1/s1
InChI key
FQYBTYFKOHPWQT-VGSWGCGISA-N
Biochem/physiol Actions
CHIR-090 is a potent, tight-binding inhibitor against LpxC, the zinc-dependent UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine deacetylase essential for gram negative bacteria lipid A biosynthesis (98% inhibition of E. coli & A. aeolicus LpxC by 0.5 μg/mL (1.15 μM) CHIR-090 at pH 7.4; A. aeolicus LpxC Ki = 1.0-1.7 nM). CHIR-090 possesses remarkable antibiotic activity comparable to that of ciprofloxacin against P. aeruginosa PAO1 as well as E. coli R477 and R477 [LpxC G17S] strains by antibacterial disk tests (20 μg/2 μL per spot).
Potent, tight-binding LpxC inhibitor with remarkable antibiotic activity comparable to that of ciprofloxacin.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable