SML3099
Glyght
≥95% (HPLC)
别名:
(E)-5-Phenyl-7-(pyridin-2-yldiazenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
质量水平
方案
≥95% (HPLC)
表单
powder
储存条件
protect from light at room temperature
颜色
yellow to orange
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
O=C1NC(C=CC(/N=N/C2=NC=CC=C2)=C3)=C3C(C4=CC=CC=C4)=NC1
InChI
1S/C20H15N5O/c26-19-13-22-20(14-6-2-1-3-7-14)16-12-15(9-10-17(16)23-19)24-25-18-8-4-5-11-21-18/h1-12H,13H2,(H,23,26)/b25-24+
InChI key
MQMSSOZUTXPEIC-OCOZRVBESA-N
一般描述
Glyght is a benzodiazepine-containing azobenzene compound that acts as a light-controlled negative allosteric modulator that is selective to glycine receptors. It is a powerful and effective compound that can operate in vivo. Glyght attaches to an allosteric site within the interface between the extracellular and transmembrane domains. It is an effective tool for researchers since it has broad activity in both homo- and heteromeric GlyRs across several species of fish and mammals. Moreover, Glyght is photo-switchable at 365 nm for trans-cis isomerization and 455 to 530 nm for cis-trans isomerization.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Alexandre M J Gomila et al.
Cell chemical biology, 27(11), 1425-1433 (2020-08-28)
Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo
Photomodulation of Inhibitory Neurotransmission. Insights from Molecular Modeling
Nin-Hill
Biophysical Journal, 118 (2020)
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