SML3099
Glyght
≥95% (HPLC)
别名:
(E)-5-Phenyl-7-(pyridin-2-yldiazenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepin-2-one
InChI
1S/C20H15N5O/c26-19-13-22-20(14-6-2-1-3-7-14)16-12-15(9-10-17(16)23-19)24-25-18-8-4-5-11-21-18/h1-12H,13H2,(H,23,26)/b25-24+
InChI key
MQMSSOZUTXPEIC-OCOZRVBESA-N
SMILES string
O=C1NC(C=CC(/N=N/C2=NC=CC=C2)=C3)=C3C(C4=CC=CC=C4)=NC1
assay
≥95% (HPLC)
form
powder
storage condition
protect from light at room temperature
color
yellow to orange
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
General description
Glyght is a benzodiazepine-containing azobenzene compound that acts as a light-controlled negative allosteric modulator that is selective to glycine receptors. It is a powerful and effective compound that can operate in vivo. Glyght attaches to an allosteric site within the interface between the extracellular and transmembrane domains. It is an effective tool for researchers since it has broad activity in both homo- and heteromeric GlyRs across several species of fish and mammals. Moreover, Glyght is photo-switchable at 365 nm for trans-cis isomerization and 455 to 530 nm for cis-trans isomerization.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Photomodulation of Inhibitory Neurotransmission. Insights from Molecular Modeling
Nin-Hill
Biophysical Journal, 118 (2020)
Alexandre M J Gomila et al.
Cell chemical biology, 27(11), 1425-1433 (2020-08-28)
Glycine receptors (GlyRs) are indispensable for maintaining excitatory/inhibitory balance in neuronal circuits that control reflexes and rhythmic motor behaviors. Here we have developed Glyght, a GlyR ligand controlled with light. It is selective over other Cys-loop receptors, is active in vivo
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