SML3147
GSK046
≥98% (HPLC)
别名:
iBET-BD2, 4-acetamido-3-fluoro-N-(trans-4-hydroxycyclohexyl)-5-[(1S)-1-phenylethoxy]benzamide; 4-Acetamido-3-fluoro-N-((1R,4S)-4-hydroxycyclohexyl)-5-((S)-1-phenylethoxy)benzamide
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关于此项目
经验公式（希尔记法）:
C23H27FN2O4
化学文摘社编号:
分子量:
414.47
UNSPSC Code:
12352107
NACRES:
NA.77
MDL number:
InChI
1S/C23H27FN2O4/c1-14(16-6-4-3-5-7-16)30-21-13-17(12-20(24)22(21)25-15(2)27)23(29)26-18-8-10-19(28)11-9-18/h3-7,12-14,18-19,28H,8-11H2,1-2H3,(H,25,27)(H,26,29)/t14-,18-,19-/m0/s1
InChI key
FRBRZGLUFOZRGD-JVPBZIDWSA-N
SMILES string
O=C(N[C@H]1CC[C@H](O)CC1)C2=CC(F)=C(NC(C)=O)C(O[C@H](C3=CC=CC=C3)C)=C2
assay
≥98% (HPLC)
form
powder
color
white to beige
storage temp.
2-8°C
Quality Level
General description
GSK046 is an orally bioavailable small molecule. Its structure contains a poly-substituted phenyl ring in the center. GSK046 reduces immuno-inflammation by inhibiting the production of monocyte chemoattractant protein 1 (MCP-1), a chemokine involved in the regulation of macrophage activation.
Biochem/physiol Actions
potent and highly selective inhibitor of bromodomain BD2 of BRD2, BDR3, BRD4, BRDT
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Progress in the development of domain selective inhibitors of the bromo and extra terminal domain family (BET) proteins
Fu Y, et al.
European Journal of Medicinal Chemistry (2021)
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