SML3170

QPD-Otf

Name: QPD-Otf
Brand: SIGMA

≥98% (HPLC)

别名:

4-chloro-2-(6-chloro-4-oxo-3,4-dihydroquinazolin-2-yl)phenyl trifluoromethanesulfonate

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关于此项目

经验公式（希尔记法）:

C₁₅H₇Cl₂F₃N₂O₄S

化学文摘社编号:

2740660-92-6

分子量:

439.19

UNSPSC Code:

12352200

NACRES:

NA.77

主要文件

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SMILES string

O=C1NC(C2=C(C=CC(Cl)=C2)OS(=O)(C(F)(F)F)=O)=NC3=CC=C(C=C31)Cl

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

2-8°C

Quality Level

100

Biochem/physiol Actions

QPD-OTf is a cell penetrant activity-based fluorogenic substrate for kinesin-1 that apparently binds to the nucleotide-binding site which removes triflate caging causing precipitation and crystallization of fluorescent QPD along microtubule cytoskeleton marking a kinesin-1 path from Golgi apparatus toward the cell periphery. QPD-OTf is not a substrate for Eg5.

cell penetrant activity-based fluorogenic substrate for kinesin-1