SML3177
2′- Deoxy-ADPR sodium salt
≥95% (HPLC)
别名:
2′-Deoxyadenosine 5′-diphosphoribose sodium salt
登录 查看组织和合同定价。
选择规格
变更视图
关于此项目
经验公式（希尔记法）:
C15H23N5O13P2 · xNa+
分子量:
543.32 (free acid basis)
UNSPSC Code:
51111800
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
oil
Quality Segment
assay
≥95% (HPLC)
form
oil
color
, Colorless to light yellow
storage temp.
-10 to -25°C
SMILES string
O[C@H]1CC(N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(O)(OP(OC[C@H]4OC(O)[C@H](O)[C@@H]4O)(O)=O)=O
InChI key
QUQXNEJSUIYECI-ANGKEQCMSA-N
Biochem/physiol Actions
2′-Deoxyadenosine 5′-diphosphoribose (2′- deoxy-ADPR) is a superagonist of the TRPM2 channel (transient receptor potential melastatin 2), a Ca2+-permeable, voltage independent, nonselective cation channel implicated in free-radical induced cell death, chemotaxis, insulin secretion, thermosensation, immune cell responses and activation of the inflammasome. 2′-Deoxy-ADPR caused 10.4-fold higher whole-cell currents at saturation than adenosine diphosphoribose (ADPR), which had been previously considered to be the main intracellular second messenger that activated TRPM2. 2′-Deoxy-ADPR decreased the inactivation rate resulting in higher average open probability.
Endogenous TRPM2 superagonist
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable