SML3189
BMS-265246
≥98% (HPLC)
别名:
(4-Butoxy-1H-pyrazolo[3,4-b]pyridin-5-yl)(2,6-difluoro-4-methylphenyl)methanone, BMS 265246, BMS265246
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About This Item
经验公式(希尔记法):
C18H17F2N3O2
CAS Number:
分子量:
345.34
MDL编号:
UNSPSC代码:
12352200
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
FC1=C(C(F)=CC(C)=C1)C(C2=C(C3=C(N=C2)NN=C3)OCCCC)=O
InChI
1S/C18H17F2N3O2/c1-3-4-5-25-17-11(8-21-18-12(17)9-22-23-18)16(24)15-13(19)6-10(2)7-14(15)20/h6-9H,3-5H2,1-2H3,(H,21,22,23)
InChI key
SCFMWQIQBVZOQR-UHFFFAOYSA-N
生化/生理作用
ATP site-targeting, potent and CDK1/CDK2-selective cyclin-dependent kinase inhibitor with anti-cancer efficacy in A2780 ovarian cancer culture.
BMS-265246 is an ATP site-targeting, potent and CDK1/2-selective cyclin-dependent kinase inhibitor (IC50 = 6 nM/CDK1, 9 nM/CDK2, 230 nM/CDK4) with anti-cancer efficacy in A2780 ovarian cancer culture (IC50 = 760 nM).
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
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