SML3197
CA77.1
≥98% (HPLC)
别名:
N-(4-(6-chloroquinoxalin-2-yl)phenyl)acetamide, N-[4-(6-Chloro-2-quinoxalinyl)phenyl]-acetamide
SMILES string
Clc1cc2ncc(nc2cc1)c3ccc(cc3)NC(=O)C
InChI key
ZQXMPDVGBWOTBY-UHFFFAOYSA-N
InChI
1S/C16H12ClN3O/c1-10(21)19-13-5-2-11(3-6-13)16-9-18-15-8-12(17)4-7-14(15)20-16/h2-9H,1H3,(H,19,21)
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
CA77.1 is an orally available, brain penetrant, in vivo active and potent enhancer of chaperone-mediated autophagy (CMA). It improves pathology in Alzheimer′s Disease mouse models. CA77.1 activates CMA in vitro without affecting macroautophagy.
orally available, brain penetrant, in vivo active and potent enhancer of chaperone-mediated autophagy (CMA)
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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