SML3210
Sotrastaurin
≥98% (HPLC)
别名:
3-(1H-Indol-3-yl)-4-(2-(4-methylpiperazin-1-yl)quinazolin-4-yl)-1H-pyrrole-2,5-dione, 3-(1H-Indol-3-yl)-4-[2-(4-methyl-piperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione, AEB 071, AEB-071, AEB071, NVP-AEB071, Sotrastaurin
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关于此项目
经验公式（希尔记法）:
C25H22N6O2
化学文摘社编号:
分子量:
438.48
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
InChI
1S/C25H22N6O2/c1-30-10-12-31(13-11-30)25-27-19-9-5-3-7-16(19)22(28-25)21-20(23(32)29-24(21)33)17-14-26-18-8-4-2-6-15(17)18/h2-9,14,26H,10-13H2,1H3,(H,29,32,33)
SMILES string
O=C(NC1=O)C(C2=CNC3=C2C=CC=C3)=C1C4=C5C=CC=CC5=NC(N6CCN(CC6)C)=N4
InChI key
OAVGBZOFDPFGPJ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
faint brown to dark red
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Orally active, ATP site-targeting, potent and selective protein kinase C (PKC) inhibitor with in vivo immunosuppressive efficacy.
Sotrastaurin (AEB071) is an orally active, ATP site-targeting, potent and selective protein kinase C (PKC) inhibitor (Ki in nM/isoform = 0.95/α, 0.64/βI, 2.1/δ, 3.2/ε, 1.8/η and 2.2/θ; IC50 = 2.1/α, 2.0/βI, 1.3/δ, 6.2/ε, 6.1/η and 1.0/θ with 10 μM ATP). Sotrastaurin inhibits TCR/CD28-mediated T cell activation in cultures (IC50 = 54 nM by Jurkat IL-2 promoter reporter line) and exhibits in vivo immunosuppressive efficacy in rat models of local graft versus host (GvH) reaction and cardiac transplantation (10 and 30 mg/kg p.o. q.d. or b.i.d.).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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