SML3211
Mogrol
≥98% (HPLC)
别名:
Mogrol, (3β,9β,10α,11α,24R)-9-Methyl-19-norlanost-5-ene-3,11,24,25-tetrol
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关于此项目
经验公式（希尔记法）:
C30H52O4
化学文摘社编号:
分子量:
476.73
UNSPSC Code:
12352107
NACRES:
NA.77
MDL number:
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
SMILES string
O[C@H]1[C@@]2([C@H]([C@]4([C@@]([C@H](CC4)[C@@H](CC[C@@H](O)C(O)(C)C)C)(C1)C)C)CC=C3[C@H]2CC[C@@H](C3(C)C)O)C
InChI
1S/C30H52O4/c1-18(9-13-24(32)27(4,5)34)19-15-16-28(6)22-12-10-20-21(11-14-23(31)26(20,2)3)30(22,8)25(33)17-29(19,28)7/h10,18-19,21-25,31-34H,9,11-17H2,1-8H3/t18-,19-,21-,22+,23+,24-,25-,28+,29-,30+/m1/s1
InChI key
JLYBBRAAICDTIS-AYEHCKLZSA-N
Biochem/physiol Actions
Mogrol is an aglycone of mogrosides from Siraitia grosvenorii that exhibits neuroprotective and anticancer activities. It induces apoptosis in K562 leukemia cells through suppression of ERK1/2 and STAT3 pathways. Mogrol appears to ameliorate the memory impairment caused by Aβ1-42 in mice. Mogrol increases AMPK activity in hepatocytes and suppresses adipocyte differentiation in 3T3-L1 cells.
aglycone of mogrosides from Siraitia grosvenorii that exhibits neuroprotective and anticancer activities; suppresses adipocyte differentiation
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Gangling Chen et al.
The Journal of pharmacy and pharmacology, 71(5), 869-877 (2018-12-27)
Cognitive impairment is the main character of Alzheimer's disease (AD). This study mainly focused on whether mogrol, a tetracyclic triterpenoids compound of Siraitia grosvenorii Swingle, can ameliorate the memory impairment induced by Aβ1-42 . Memory impairment mice model was made
Can Liu et al.
American journal of cancer research, 5(4), 1308-1318 (2015-06-24)
Unlike solid tumors, the primary strategy for leukemia treatment is chemotherapy. However, leukemia chemotherapy is associated with adverse drug effects and drug resistance. Therefore, it is imperative to identify novel agents that effectively treat leukemia while minimizing adverse effects. The
Naoki Harada et al.
PloS one, 11(9), e0162252-e0162252 (2016-09-02)
This study investigated the effects of mogrol, an aglycone of mogrosides from Siraitia grosvenorii, on adipogenesis in 3T3-L1 preadipocytes. Mogrol, but not mogrosides, suppressed triglyceride accumulation by affecting early (days 0-2) and late (days 4-8), but not middle (days 2-4)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML3211-25MG | 04065267368894 |
| SML3211-5MG | 04065267368900 |