SML3219

Tenofovir alafenamide

Name: Tenofovir alafenamide
Brand: SIGMA

≥98% (HPLC), HIV and HBV reverse transcriptase inhibitor, powder

别名:

9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino]phenoxyphosphinyl]-methoxy]-propyl]adenine, GS 7340, GS-7340, GS7340, TAF

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₉N₆O₅P

化学文摘社编号:

379270-37-8

分子量:

476.47

NACRES:

NA.77

UNSPSC Code:

51111800

MDL number:

MFCD28976050

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产品名称

Tenofovir alafenamide, ≥98% (HPLC)

InChI

1S/C21H29N6O5P/c1-14(2)31-21(28)16(4)26-33(29,32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9,11-12,14-16H,10,13H2,1-4H3,(H,26,29)(H2,22,23,24)/t15-,16+,33+/m1/s1

SMILES string

CC(OC([C@@H](N[P@](CO[C@@H](CN1C2=NC=NC(N)=C2N=C1)C)(OC3=CC=CC=C3)=O)C)=O)C

InChI key

LDEKQSIMHVQZJK-CAQYMETFSA-N

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

HIV and HBV reverse transcriptase inhibitor tenofovir isopropylalaninyl phenyl ester with greater antiviral efficacy than tenofovir disoproxil fumarate.

Tenofovir alafenamide (TAF; GS-7340) is an isopropylalaninyl phenyl ester prodrug of the nucleotide analog reverse transcriptase inhibitor (nRTI) tenofovir (TFV) against human immunodeficiency virus (HIV) and hepatitis B virus (HBV). GS-7340 more efficiently delivers TFV into lymphoid cells and tissues than tenofovir disoproxil fumarate (TDF), resulting in greater antiviral efficacy against HIV.