SML3223
CAY10566
≥98% (HPLC)
别名:
2-(6-(4-(2-Chloro-5-fluorophenoxy)piperidin-1-yl)pyridazin-3-yl)-5-methyl-1,3,4-oxadiazole, Abbott compound 74, Abbott-28c, CAY 10566, CAY-10566, SCD1 inhibitor 28c
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关于此项目
经验公式（希尔记法）:
C18H17ClFN5O2
化学文摘社编号:
分子量:
389.81
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
Fc1cc(c(cc1)Cl)OC2CCN(CC2)c3nnc(cc3)c4nnc([o]4)C
InChI
1S/C18H17ClFN5O2/c1-11-21-24-18(26-11)15-4-5-17(23-22-15)25-8-6-13(7-9-25)27-16-10-12(20)2-3-14(16)19/h2-5,10,13H,6-9H2,1H3
InChI key
WFOFPVXMPTVOTJ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
off-white to orange
solubility
DMSO: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
CAY10566 is a potent and selective stearoyl-CoA desaturase 1 (SCD1) inhibitor (IC50 = 26 nM/hSCD1 and 4.5 nM/mSCD1; IC50 >10 μM/75 receptors, transporters, ion channels). CAY10566 effectively blocks the conversion of saturated long-chain fatty acid-CoAs (LCFA-CoAs) to monounsaturated LCFA-CoAs in HepG2 cells (IC50 = 7.9 nM by C17:1/C17:0 ratio; IC50 = 6.8 nM by C16:1/C16:0 ratio) and exhibits good metabolic stability (by rat & mouse liver microsome assays) and oral availability (rat F = 59.2%; 5 mg/kg p.o.). CAY10566 is typically used in the range from 0.1-10 μM for cell treatment.
Orally available, potent and selective stearoyl-CoA desaturase 1 (SCD1) inhibitor.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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