SML3273
XAF-1407
≥98% (HPLC)
别名:
(3-methyl-1-[5-phenyl-4-[4-(2-pyrrolidin-1-ylethoxymethyl)-1-piperidyl]thieno[2,3-d]pyrimidin-6-yl]azetidin-3-ol)
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
OC1(CN(C1)C2=C(C3=C(N=CN=C3S2)N4CCC(CC4)COCCN5CCCC5)C6=CC=CC=C6)C
InChI
1S/C28H37N5O2S/c1-28(34)18-33(19-28)27-23(22-7-3-2-4-8-22)24-25(29-20-30-26(24)36-27)32-13-9-21(10-14-32)17-35-16-15-31-11-5-6-12-31/h2-4,7-8,20-21,34H,5-6,9-19H2,1H3
InChI key
AVTFTJSBFXQTLR-UHFFFAOYSA-N
相关类别
生化/生理作用
Potent and highly selective inhibitor of the acetylcholine-activated inward rectifier potassium current (IKACh) that exhibits an antiarrhythmic effect
XAF-1407 is a potent and highly selective inhibitor of the acetylcholine-activated inward rectifier potassium current (IKACh) that exhibits an antiarrhythmic effect in a goat and horse models of atrial fibrillation. XAF-1407 potently and selectively inhibits ion channels formed by Kir3.1/3.4 heterotetramers and Kir3.4 homotetramers that carry the IKACh current (IC50 of 1.1 and 3.2 nM respectively).
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Vladimír Sobota et al.
Frontiers in pharmacology, 11, 608410-608410 (2021-02-16)
Aims: The acetylcholine-activated inward rectifier potassium current (IKACh) has been proposed as an atrial-selective target for the treatment of atrial fibrillation (AF). Using a novel selective IKACh inhibitor XAF-1407, the study investigates the effect of IKACh inhibition in goats with
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