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Merck
CN

SML3275

Vamorolone

≥95% (HPLC)

别名:

(16α)-17,21-Dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione, (16α)-17,21-Dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione;, VBP 15, VBP15

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关于此项目

经验公式(希尔记法):
C22H28O4
化学文摘社编号:
分子量:
356.46
UNSPSC Code:
12352200
NACRES:
NA.84
MDL number:
Assay:
≥95% (HPLC)
Form:
powder
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Quality Segment

assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

O[C@]1([C@@]2([C@H]([C@@H]3CCC4=CC(=O)C=C[C@@]4(C3=CC2)C)C[C@H]1C)C)C(=O)CO

InChI

1S/C22H28O4/c1-13-10-18-16-5-4-14-11-15(24)6-8-20(14,2)17(16)7-9-21(18,3)22(13,26)19(25)12-23/h6-8,11,13,16,18,23,26H,4-5,9-10,12H2,1-3H3/t13-,16-,18+,20+,21+,22+/m1/s1

InChI key

ZYTXTXAMMDTYDQ-DGEXFFLYSA-N

Biochem/physiol Actions

Orally available dissociative steroid with anti-inflammatory efficacy
Vamorolone, a synthetic steroid, is an orally available dissociative steroid with anti-inflammatory efficacy. It is a partial agonist of the glucocorticoid receptor (NR3C1) that appear to be safe and well tolerated. Also, vamorolone is a potent antagonist of the mineralocorticoid receptor (NR3C2). It is under development for children with Duchenne muscular dystrophy.


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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全球贸易项目编号

货号GTIN
SML3275-25MG04065268005163
SML3275-5MG04065268005170