SML3275
Vamorolone
≥95% (HPLC)
别名:
(16α)-17,21-Dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione, (16α)-17,21-Dihydroxy-16-methylpregna-1,4,9(11)-triene-3,20-dione;, VBP 15, VBP15
质量水平
方案
≥95% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: 2 mg/mL, clear
储存温度
−20°C
SMILES字符串
O[C@]1([C@@]2([C@H]([C@@H]3CCC4=CC(=O)C=C[C@@]4(C3=CC2)C)C[C@H]1C)C)C(=O)CO
InChI
1S/C22H28O4/c1-13-10-18-16-5-4-14-11-15(24)6-8-20(14,2)17(16)7-9-21(18,3)22(13,26)19(25)12-23/h6-8,11,13,16,18,23,26H,4-5,9-10,12H2,1-3H3/t13-,16-,18+,20+,21+,22+/m1/s1
InChI key
ZYTXTXAMMDTYDQ-DGEXFFLYSA-N
生化/生理作用
Orally available dissociative steroid with anti-inflammatory efficacy
Vamorolone, a synthetic steroid, is an orally available dissociative steroid with anti-inflammatory efficacy. It is a partial agonist of the glucocorticoid receptor (NR3C1) that appear to be safe and well tolerated. Also, vamorolone is a potent antagonist of the mineralocorticoid receptor (NR3C2). It is under development for children with Duchenne muscular dystrophy.
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Christopher R Heier et al.
Life science alliance, 2(1) (2019-02-13)
Cardiomyopathy is a leading cause of death for Duchenne muscular dystrophy. Here, we find that the mineralocorticoid receptor (MR) and glucocorticoid receptor (GR) can share common ligands but play distinct roles in dystrophic heart and skeletal muscle pathophysiology. Comparisons of
Xu Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(39), 24285-24293 (2020-09-13)
Duchenne muscular dystrophy is a genetic disorder that shows chronic and progressive damage to skeletal and cardiac muscle leading to premature death. Antiinflammatory corticosteroids targeting the glucocorticoid receptor (GR) are the current standard of care but drive adverse side effects
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