质量水平
方案
≥98% (HPLC)
表单
powder
颜色
, White to very dark gray
溶解性
DMSO: 2 mg/mL, clear
储存温度
2-8°C
SMILES字符串
CC(C=C1)=CC=C1OC2=CC=NC3=CC(C4=CN(C5CCNCC5)N=C4)=CC=C23
InChI
1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3
InChI key
VPVLPCIBKVWFDT-UHFFFAOYSA-N
生化/生理作用
HS-1371 is a potent ATP-competitive RIP3 (RIPK3) kinase inhibitor (IC50 = 20.8 nM, [ATP] = 10 μM) that blocks RIP3 S227 autophosphorylation and selectively suppresses TNF/SMAC mimetic/Z-VAD-FMK agonist treatment-induced necroptosis induction in HT-29 cultures (by 44.4% at 1 μM, by 77.7% at 5 μM) in a RIP3- and MLKL-dependent manner.
Potent ATP-competitive RIP3 (RIPK3) kinase inhibitor that suppresses necroptosis in a RIP3- and MLKL-dependent manner.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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