SML3282
HS-1371 trifluoroacetate salt
≥98% (HPLC)
别名:
4-(4-methylphenoxy)-7-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-quinoline trifluoroacetate salt, 7-(1-(Piperidin-4-yl)-1H-pyrazol-4-yl)-4-(p-tolyloxy)quinoline trifluoroacetate salt, HS 1371, HS1371
Quality Level
storage temp.
2-8°C
InChI
1S/C24H24N4O/c1-17-2-5-21(6-3-17)29-24-10-13-26-23-14-18(4-7-22(23)24)19-15-27-28(16-19)20-8-11-25-12-9-20/h2-7,10,13-16,20,25H,8-9,11-12H2,1H3
InChI key
VPVLPCIBKVWFDT-UHFFFAOYSA-N
SMILES string
CC(C=C1)=CC=C1OC2=CC=NC3=CC(C4=CN(C5CCNCC5)N=C4)=CC=C23
assay
≥98% (HPLC)
form
powder
color
, White to very dark gray
solubility
DMSO: 2 mg/mL, clear
Biochem/physiol Actions
HS-1371 is a potent ATP-competitive RIP3 (RIPK3) kinase inhibitor (IC50 = 20.8 nM, [ATP] = 10 μM) that blocks RIP3 S227 autophosphorylation and selectively suppresses TNF/SMAC mimetic/Z-VAD-FMK agonist treatment-induced necroptosis induction in HT-29 cultures (by 44.4% at 1 μM, by 77.7% at 5 μM) in a RIP3- and MLKL-dependent manner.
Potent ATP-competitive RIP3 (RIPK3) kinase inhibitor that suppresses necroptosis in a RIP3- and MLKL-dependent manner.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
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Oncogene, 40(29), 4783-4795 (2021-06-23)
Triple-negative breast cancer (TNBC) is the most aggressive molecular subtype among breast tumors and remains a challenge even for the most current therapeutic regimes. Here, we demonstrate that oncolytic alphavirus M1 effectively kills both TNBC and non-TNBC. ER-stress and apoptosis
Han-Hee Park et al.
Experimental & molecular medicine, 50(9), 1-15 (2018-09-22)
Necroptosis is a type of programmed cell death that usually occurs under apoptosis-deficient conditions. Receptor-interacting protein kinase-3 (RIP3, or RIPK3) is a central player in necroptosis, and its kinase activity is essential for downstream necroptotic signaling events. Since RIP3 kinase
Jimin Jeon et al.
Annals of the rheumatic diseases, 79(12), 1635-1643 (2020-09-09)
Recently, necroptosis has attracted increasing attention in arthritis research; however, it remains unclear whether its regulation is involved in osteoarthritis (OA) pathogenesis. Since receptor-interacting protein kinase-3 (RIP3) plays a pivotal role in necroptosis and its dysregulation is involved in various
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