SML3283
T-0080
≥98% (HPLC)
别名:
3-(2-Hydroxy-5-methylphenyl)-5-(tetrahydro-2H-pyran-4-yl)-4-(4-(trifluoromethyl)phenyl)-4,5-dihydropyrrolo[3,4-c]pyrazol-6(2H)-one, T 0080, T0080
InChI
1S/C24H22F3N3O3/c1-13-2-7-18(31)17(12-13)20-19-21(29-28-20)23(32)30(16-8-10-33-11-9-16)22(19)14-3-5-15(6-4-14)24(25,26)27/h2-7,12,16,22,31H,8-11H2,1H3,(H,28,29)
InChI key
NLNJUYHGBAJDBQ-UHFFFAOYSA-N
SMILES string
O=C1N(C2CCOCC2)C(C3=CC=C(C(F)(F)F)C=C3)C4=C(C5=C(O)C=CC(C)=C5)NN=C41
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Blood-brain barrier (BBB)-permeable formyl peptide receptor 1 (FPR1) antagonist with therapeutic efficacy in murine intracerebral hemorrhage (ICH) models in vivo.
T-0080 is a blood-brain barrier (BBB)-permeable formyl peptide receptor 1 (FPR1) antagonist that effectively inhibits fMLF-dependent response in human and murine neutrophils cultures (10 nM fMLF-induced human neutrophil Ca2+ response IC50 = 0.85 μM) and attenuates brain edema and improved neurological outcomes in murine intracerebral hemorrhage (ICH) models in vivo (5 mg/kg via daily i.p.) with no short-term adverse effects (up to 2 g/kg p.o.).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Zhiguo Li et al.
Science translational medicine, 13(605) (2021-08-06)
Acute brain insults elicit pronounced inflammation that amplifies brain damage in intracerebral hemorrhage (ICH). We profiled perihematomal tissue from patients with ICH, generating a molecular landscape of the injured brain, and identified formyl peptide receptor 1 (FPR1) as the most
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