SML3289
Synucleozid dihydrochloride
≥98% (HPLC)
别名:
2-(4-(4-Carbamimidoylphenylamino)phenyl)-1H-indole-6-carboximidamide, dihydrochloride, 2-[4-(4-Carbamimidoylanilino)phenyl]-1H-indole-6-carboximidamide, dihydrochloride, 2-[4-[[4-(Aminoiminomethyl)phenyl]amino]phenyl]-1H-indole-6-carboximidamide, dihydrochloride, NSC 377363 2HCl, NSC-377363 2HCl, NSC377363 2HCl
SMILES string
[nH]1c2c(cc1c3ccc(cc3)Nc4ccc(cc4)C(=N)N)ccc(c2)C(=N)N
InChI
1S/C22H20N6/c23-21(24)14-5-9-18(10-6-14)27-17-7-3-13(4-8-17)19-11-15-1-2-16(22(25)26)12-20(15)28-19/h1-12,27-28H,(H3,23,24)(H3,25,26)
InChI key
TZRXNWCLKYWDNH-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
, White to very dark grey
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Selective α-synuclein (α-syn) translation inhibitor with cytoprotective efficacy against preformed α-syn fibrils (PFFs) in SH-SY5Y neuronal cultures.
Synucleozid is a selective α-synuclein (α-syn) translation inhibitor (46% & 69% α-syn downregulation post 48 h, respectively, with 0.5 or 1 μM Synucleozid) with cytoprotective efficacy against preformed α-synuclein fibrils (PFFs) in SH-SY5Y neuronal cultures (56% protection; 0.5 μM Synucleozid added 24 h prior to 48 h 50 μg/mL PFFs exposure). Synucleozid directly and selectively targets α-syn (SNCA) mRNA 5′ UTR at the iron-responsive element (IRE) site, effectively interfering with the polysomes assembly onto SNCA mRNA.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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