SML3330
MRK-560
≥98% (HPLC)
别名:
MRK 560, MRK560, N-[cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexyl]-1,1,1-trifluoromethanesulfonamide
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关于此项目
经验公式（希尔记法）:
C19H17ClF5NO4S2
化学文摘社编号:
分子量:
517.92
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
SMILES string
FC(F)(F)[S](=O)(=O)N[C@@H]1CC[C@@](CC1)([S](=O)(=O)c3ccc(cc3)Cl)c2c(ccc(c2)F)F
InChI
1S/C19H17ClF5NO4S2/c20-12-1-4-15(5-2-12)31(27,28)18(16-11-13(21)3-6-17(16)22)9-7-14(8-10-18)26-32(29,30)19(23,24)25/h1-6,11,14,26H,7-10H2/t14-,18+
InChI key
WDZVWDXOIGQJIO-UJKQEGAGSA-N
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
Brain-penetrant, orally active, highly potent and selective gamma-secretase inhibitor with CNS Aβ40-lowering efficacy in mice and rats in vivo.
MRK-560 is a brain-penetrant, orally active, highly potent and selective gamma-secretase inhibitor (GSI; IC50 = 0.65 nM by SH-SY5Y cellular γ-secretase substrate A4CTF breakdown assay) with little inhibitory potency against a panel of 171 enzymes/receptors. MRK-560 blocks Aβ40 & Aβ42 production with similar potency in SH-SY5Y cultures (IC50 <0.5 nM) and lowers CNS Aβ40 in rats (brain & SCF ED50 in 8h = 6 & 10 mg/kg po.) and APP-YAC mice (brain ED50 in 4h <3 mg/kg po.) in vivo
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
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